Abstract:

AIM: To assess the status of antidiabetic agents usage in inpatients with type 2 diabetes mellitus in our hospital and provide clinical reference for rational administration of drug.  METHODS: The inpatients with type 2 diabetes mellitus were recruited and the data of age, diabetes duration, blood sugar, therapeutic management were collected from June, 2014 to September, 2014 in department of endocrinology. Therapeutic managements were divided into oral antidiabetic agents, insulin only and oral antidiabetic agents plus insulin. Combined medication strategies were divided into single drug group, two drugs group, three and more drugs group. RESULTS:A total of 175 patients with type 2 diabetes mellitus were enrolled. Patients in insulin only and oral antidiabetic agents plus insulin groups exhibited a significantly higher increase in diabetes duration, FPG, HbA1c, but lower concentration of C0 and C2h compared with patients in oral antidiabetic agents group (P<0.05). In addition, the patients of three and more drugs group had higher values of BMI and FPG than patients in single drug group (P<0.05). CONCLUSION: When the level of HbA1c is relatively higher and the diabetes duration is longer in our hospital, the patients with type 2 diabetes mellitus are given insulin. The opportunity to start the insulin therapy is too late to cause the higher risk of chronic complications. The unilization ratio of metformin is relatively lower, which fails to play the role of first-line drug.

Key words: type 2 diabetes mellitus, antidiabetic agents, therapeutic strategy, rational use of drug