关键词: Th17细胞, IL-17, 呼吸道合胞病毒, 毛细支气管炎, 气道炎症

Abstract: Objective To investigate the correlation between Th17 cell(Th17) , Interleukine-17(IL-17) and airway inflammation through examining the concentration changes of Th17 and IL-17 in serum of children who were suffering from respiratory syncytial virus (RSV) bronchiolitis. Methods Forty infants with the primary RSV bronchiolitis were recruited in this study.Two milliliter blood samples were collected in the acute phase and the recovery phase, respectively.The ratio of Th17 cell was analyzed by flow cytometry, and the concentration of IL-17 was analyzed by and ELISA. Results The ratio of Th17 cell and the concentration of IL-17 in the acute phase of RSV bronchiolitis were both significantly higher than those in the recovery phase(P＜0.01).Moreover, compared to children with mild RSV bronchiolitis, these two indexes in children with severe RSV bronchiolitis were both increased significantly in the acute phase (P＜0.01), but no significant changes were detected in the recovery phase(P＞0.05). Conclusions Th17 cells and IL-17 might be involved in the airway inflammation in the acute phase of RSV bronchiolitis, and be associated with the severity of the disease.

Key words: Th17 cell, Interleukine-17, respiratory syncytial virus, bronchiolitis, airway inflammation