联合接种肺炎球菌疫苗与流感疫苗对反复呼吸道感染患儿健康相关生活质量的影响研究

doi:10.11852/zgetbjzz2014-22-04-23

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (4): 411-413.DOI: 10.11852/zgetbjzz2014-22-04-23

联合接种肺炎球菌疫苗与流感疫苗对反复呼吸道感染患儿健康相关生活质量的影响研究

李晓岚¹, 李晓军¹, 鲁金玲¹, 谢帆²

1 武汉市汉口医院儿科, 湖北武汉 430012;
2 武汉市江岸区金桥社区卫生服务中心, 湖北武汉 430014

收稿日期:2013-10-23 发布日期:2014-04-10 出版日期:2014-04-10
通讯作者: 李晓军, E-mail:lixiaojunerke@126.com
作者简介:李晓岚(1972-), 湖北人, 学士学位, 主要从事儿科的相关研究。
基金资助:
湖北省武汉市卫生局医学科研项目(WG-10C11)

Study on health-related quality of life of children with recurrent respiratory tract infection simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine.

LI Xiao-lan¹, LI Xiao-jun¹, LU Jin-ling¹, XIE Fan².

1 Department of Pediatrics, Hankou Hospital of Wuhan City, Wuhan, Hubei 430012, China; 2 Jinqiao Community Health Service Center of Wuhan Jiang'an District, Wuhan, Hubei 430014, China

Received:2013-10-23 Online:2014-04-10 Published:2014-04-10
Contact: LI Xiao-jun, E-mail:lixiaojunerke@126.com

摘要/Abstract

摘要： 目的观察肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(recurrent respiratory tract infection, RRTI)患儿健康相关生活质量(health-related quality of life, HRQOL)的影响。方法 278例RRTI患儿随机分为两组, 对照组(n=135例)仅使用安慰剂, 疫苗接种组(n=143例)联合接种肺炎球菌疫苗与流感疫苗, 观察两组患儿相关临床指标以及接种前、接种后14个月、接种后26个月时的PedsQL^TM 4.0评分。结果两组患儿在例数、性别、年龄、病程及SES评分等方面比较差异无统计学意义(P>0.05);疫苗接种组患儿上、下呼吸道感染次数, 呼吸道疾病所致发热次数, 抗生素使用天数及总治疗费用均明显少于对照组(P<0.05);两组接种前PedsQL^TM 4.0评分比较差异无统计学意义(P>0.05), 疫苗接种组随接种时间延长, 各维度生活质量均明显提高(P<0.05), 而对照组差异无统计学意义(P>0.05)。结论肺炎球菌疫苗与流感疫苗联合接种可有效改善RRTI患儿的HRQOL, 明显提高PedsQL^TM 4.0评分, 值得临床推广应用。

关键词: 反复呼吸道感染, 肺炎球菌, 流感, 疫苗, 健康相关生活质量

Abstract: Objective To observe the health-related quality of life(HRQOL) of children with recurrent respiratory tract infection (RRTI)simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine. Methods A total of 278 cases RRTI were randomly divided into two groups.The control group (n=135 patients) was used with placebo only while the vaccine group (n=143 patients) was simultaneously inoculated with pneumococcal vaccination combined with influenza vaccine.The PedsQL^TM 4.0 scores and clinical indicators were observed in each group before the inoculations; 14 months and 26 months after the inoculation. Results There were no significant differences in the number of cases, gender, age, duration and SES score in the two groups (P>0.05);The incidence of upper and lower respiratory tract infection, respiratory diseases caused by the frequency of fever, the number of days of antibiotic use and total cost of treatment in the vaccine group were significantly less than those of the control group (P<0.05);The PedsQL^TM 4.0 score showed no significant difference in both groups(P>0.05) before the inoculation;Each dimension of the quality of life of the vaccine group significantly increased as inoculation time extended (P<0.05), while those of control group showed no significant difference (P>0.05). Conclusion Combination of inoculation of pneumococcal vaccine and influenza vaccine can effectively improve the HRQOL of RRTI children as well as the PedsQL^TM 4.0 score and it should be highly recommended clinically.

Key words: recurrent respiratory tract infection, pneumococcal, influenza, vaccine, health-related quality of life

中图分类号:

R725.6

李晓岚, 李晓军, 鲁金玲, 谢帆. 联合接种肺炎球菌疫苗与流感疫苗对反复呼吸道感染患儿健康相关生活质量的影响研究[J]. 中国儿童保健杂志, 2014, 22(4): 411-413.

LI Xiao-lan, LI Xiao-jun, LU Jin-ling, XIE Fan.. Study on health-related quality of life of children with recurrent respiratory tract infection simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine.[J]. journal1, 2014, 22(4): 411-413.

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联合接种肺炎球菌疫苗与流感疫苗对反复呼吸道感染患儿健康相关生活质量的影响研究

Study on health-related quality of life of children with recurrent respiratory tract infection simultaneously inoculated by pneumococcal vaccine combined with influenza vaccine.

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