关键词: 早产儿, 维生素D, 补充, 新生儿早期, 免疫功能

Abstract: Objective To study the effect of vitamin D supplementation in early preterm infants on the immune function. Methords The 158 preterm infants from Cangzhou People's Hospital were selected in the study,and were divided into the large for gestational age group and small for gestational age group.Each group was randomly divided into control group and experimental group.The control group was given formula feeding.The experimental group on the basis of the control group,was fed vitamin D intake 400 U/d from 3rd to 10th day after birth.Serum 25-(OH) D,IL-2 and IgG,IgA,IgM were tested before and after the experiment,and vitamin D toxicity was observed. Results It was high prevalence of moderately severe vitamin D deficiency in preterm infants.Serum 25-(OH) D level of experimental group was significantly higher than that of the control group(P＜0.05).In the small and large for gestational age group,vitamin D supplementation of 400 U/d respectively increased mean 25-(OH)D levels from 23.556 nmol/L,27.771 nmol/L at birth to 27.423 nmol/L,32.198 nmol/L at discharge.With the development of 25-(OH) D level,IL-2 level increased significantly,experimental group had significant difference compared with the control (P<0.05),while IgG,IgA,IgM had no significant change (P>0.05). Conclusions Early vitamin D supplementation can improve immunity of premature infants.Further research is required on the effect on humoral immunity.

Key words: preterm infants, vitamin D, supplement, early neonatal, immunologic function