关键词: MCR4, 基因多态性, 儿童, 肥胖, Meta分析

Abstract: Objective To apply a Meta-analysis of various studies from different ethnic populations and assess the association of the melanocortin 4 receptor(MC4R) polymorphism with childhood obesity. Methods All published literature were retrieved that investigated association of MC4R variants with obesity from PubMed,CNKI and Wanfang database.Pooled odds ratio (OR) with 95% confidence interval (CI) and weighted mean difference (WMD) were calculated using fixed- or random-effects model. Results A total of 12 case-control studies were eligible for this analysis.Meta-analysis showed that MC4R rs17782313 increased the risk of childhood obesity in all models (CC vs TT,OR=1.84,95%CI:1.44~2.36;CC vs CT,OR=1.48,95%CI:1.29~1.70,P_het=0.756;CC vs TT/TC,OR=1.67,95%CI:1.39~1.99;TC/CC vs TT,OR=1.35,95%CI:1.19~1.55).Moreover,the association between genotypes and childhood the body mass index (BMI) Z-score was also significant (WMD=0.14,95%CI:0.06~0.23,CC vs TT). Conclusion The present meta-analysis confirms the association of MC4R polymorphism with risk of childhood obesity.

Key words: melanocortin 4 receptor, polymorphism, children, obesity, Meta-analysis