关键词: 超重, 肥胖症, 儿童及青少年, 促甲状腺激素

Abstract: Objective To analyze the correlation between thyroid stimulating hormone (TSH) and overweight and obese children and adolescents, in order to provide reference for clinical intervention and treatment. Methods Children and adolescents aged 3-18 years who took health examination in the Second Affiliated Hospital of Wenzhou Medical University from April 2016 to April 2017 were selected into the study. Totally 385 children were enrolled, including 183 controls,116 overweight children and 83 obese children. Clinical data and thyroid functions of three groups were compared and analyzed. Results The levels of TSH, alanine aminotransferase(ALT), triglyceride(TG), cholesterol(TC),low density lipoprotein(LDL), uric acid(UA), fasting insulin(Fins), HOMA index (HOMA-β, HOMA-IR) gradually increased among control, overweight and obesity groups (P<0.05). Different degrees of thyroid dysfunction were found in 15.30% of the children with overweight and obesity. The obesity rate was significantly higher in high TSH group (P<0.01). With the increasing of TSH concentration, the incidences of ALT, GGT, TG showed gradually ascending trends respectively, while HDL decreased on the contrary. Multivariate Logistics regression analysis showed that TSH might not be an independent risk factor of overweight and obesity in children and adolescents. Conclusions In the children and adolescents with overweight or obesity, there were some metabolic abnormalities such as increasing level of liver enzymes, hyperlipidaemia, hyperuricemia. Meanwhile, obesity group tends to develop thyroid dysfunction, with higher level of TSH. Moreover, the increasing of TSH level might be an adaptive change after obesity.

Key words: overweight, obesity, children and adolescents, thyroid stimulating hormone