关键词: 25羟维生素D, 佝偻病, 母亲, 婴儿

Abstract: Objective Toanalyze the correlation of serum vitamin D level between exclusively breast-fed infants aged 28~42 days with clinical manifestation of rickets and their mothers,in order to provide theoretical foundation for prevention of infant nutritional rickets. Methods A total of 119 exclusively breast-fed infants in Northwest Women and Children Hospital,diagnosed with nutritional rickets at age of 28~42 days,were enrolled in this study from April 2016 to October 2017. Serum 25-hydroxylvitamin D [25-(OH)D] level of both infants and their mothers were tested and the correlation was analyzed. Results Among the 119 mothers,15(12.61%) mothers had serum 25-(OH)D level higher than 30 ng/ml,104(87.39%) mothers were no more than 30 ng/ml. Totally 19 mothers took vitamin D supplementation ≥400 U per day during pregnancy,and the median serum level of 25-(OH)D was 28.8 ng/ml. And 100 mothers took vitamin D supplementation less than 400 U per day during pregnancy,and the median serum level of 25-(OH)D was 16.1 ng/ml. The difference on the median serum level of 25-(OH)D between the two groups was significant(P＜0.05). Also,there was significant difference on the median serum level of 25-(OH)D between infants with and without vitamin D supplementation(20.0 ng/ml vs.9.5 ng/ml,P＜0.05). The serum 25-(OH)D level of infants was positively correlated with theirs mothers' level. No correlation was found between serum 25-(OH)D level(20ng/ml as cutting edge) and the possibility of rickets symptoms and signs. Conclusions The overall vitamin D level of both infants and their mothers is insufficient,and the serum 25-(OH)D level between the infants and their mothers are significantly related. It is suggested to take vitamin D supplementation during pregnancy and to give infants vitamin D supplementation immediately after birth,so as to prevent nutritional rickets in infants.

Key words: 25-(OH)D, rickets, mother, infants