关键词: 脑干听觉诱发电位, 神经心理发育, 预测, 婴幼儿

Abstract: Objective To analyze the predictive validity of brainstem auditory evoked potential(BAEP) or auditory brainstem response(ABR) on neuropsychological development in infants and young children,in order to provide scientific evidence for the effect of persistent BAEP abnormality on neuropsychological development in infants aged 2 years. Methods Totally 95 premature babies born in Hubei Maternal and Child Health Hospital from June 2014 to October 2015 were selected as participants. The average gestational age was (34.3±1.7) weeks and the weight was (2.457±0.268) kg. There were 100 full-term infants with an average gestational age of (38.3±1.9) weeks with a weight of (3.457±0.328) kg. Bayley Infant Development Scale was followed up to 2 years old,and BAEP was monitored at the age of 1,3 and 6 months. The relationship between normal and abnormal BAEP results at the age of 6 months old and neuropsychological development at 2 years old was observed. Results The mental development indexes (MDI) at the age of 2 years old in preterm infants with abnormal BAEP aged 28-32 weeks,32-34 weeks,35-36 weeks and full-term infants were 80.63±5.216,83.43±3.563,86.36±7.658 and 90.12±5.658,respectively. While the MDIs at the age of 2 years old in infants with normal BEAP results in those children were 89.75±5.249,94.30±7.740,94.44±7.570 and 93.89±9.752,respectively. The differences were significant among the groups (P<0.05). Conclusion BAEP monitoring at the age of 6 months old is a sensitive index for predicting the level of neuropsychological development at 2 years old.

Key words: brainstem auditory evoked potential, neuropsychological development, prediction, infants