关键词: IL-10, TGF-β, 牛奶蛋白过敏, 食物过敏, 婴儿

Abstract: Objective To study the roles of interlukin-10(IL-10) and transforming and growth factor-β(TGF-β) in pathogenesis of cow′s milk protein allergy(CMPA) in infants,in order to analyze the role of IL-10 and TGF-β in the process of cow′s milk protein allergy.Methods A total of 20 infants diagnosed with CMPA by oral food challenge(OFC) test in Shenzhen Maternity and Child Healthcare Hospital from January to June in 2018 were enrolled in CMPA group,meanwhile 15 healthy infants were selected as control group. Serum levels of IL-10,TGF-β and IgG4 were tested by enzyme-linked immunosobent assay,and total IgE and milk specific IgE were assayed as well. Results There were 5 cases with total IgE＞200,2 cases with total IgE between 100 and 200,13 cases with total IgE＜100 in CMPA group. Serum levels of IL-10,TGF-β and IgG4 in CMPA group were significantly lower than those of control group(t=-3.130,-2.811,-3.463,P＜0.05). CMPA group was divided into IgE positive sub-group and IgE negative sub-group,and there was no significant difference on IgG4 level between the two groups(t=-0.781,P＞0.05). Conclusions IL-10 and TGF-β play important roles in pathogenesis of CMPA in infants. On the contrary,there may be no significant correlation between IgG4 and IgE. It is necessary to know the prognosis and immunotolerance of infants with CMPA by dynamic observation of IL-10 and TGF-β.

Key words: interlukin-10, transforming and growth factor-β, cow′s milk protein allergy, food allergy, infant