关键词: 网膜素-1, 非酒精性脂肪肝, 脂肪因子, 儿童

Abstract: Objective To evaluate the associations between omentin-1 and childhood non-alcoholic fatty liver disease (NAFLD). Methods A total of 116 obese children were divided into NAFLD with obesity (n=61) and without obesity(n=55) group, and 55 children with normal weight were as control. The height, weight, waist circumference and blood pressure were measured.The blood lipid, blood glucose and biochemical test were also tested. Venous blood was collected to detect serum insulin, omentin-1,leptin and adiponectin and analyze the correlation. Logistics regression analysis was used to evaluate the risk and protected factors of NAFLD. And ROC curve was used to assess diagnostic value of omentin-1, body mass index(BMI)and waist circumference for NAFLD. Results Serum omentin-1 level was significantly lower in obese children with NAFLD compared with other two groups(P<0.05). After adjusted for age and waist circumference, omentin-1 was negatively correlated with NAFLD,low-density lipoprotein level(LDL-C) and leptin/adiponectin (LAR), and was positively correlated with adiponectin (all P<0.05). Furthermore, Logistics regression analysis showed BMI, HOMA-IR were risk factors for NAFLD, and omentin-1 was a protected factor (P<0.05). BMI, waist circumference and omentin-1 were helpful for NAFLD diagnosis. Conclusion Serum omentin-1 is related to childhood body lipid especially central obesity,lipid disorder and NAFLD, which may be a beneficial adiposity factor helpful to improve childhood NAFLD.

Key words: omentin-1, non-alcoholic fatty liver disease, adipokine, children