孕期缺铁对婴幼儿运动发育的研究进展

doi:10.11852/zgetbjzz2019-0158

中国儿童保健杂志 ›› 2019, Vol. 27 ›› Issue (11): 1192-1195.DOI: 10.11852/zgetbjzz2019-0158

孕期缺铁对婴幼儿运动发育的研究进展

李明燕综述 , 赵正言审校

浙江大学医学院附属儿童医院,儿童保健科,浙江杭州 310003

收稿日期:2019-02-13 发布日期:2019-11-10 出版日期:2019-11-10
通讯作者: 赵正言,E-mail:zhaozy@zju.edu.cn
作者简介:李明燕(1984-),女,浙江人,主治医师,博士学位,主要研究方向为高危儿的营养管理及神经发育研究。
基金资助:
浙江省自然科学基金青年基金(LQ19H260003);中央高校基本科研业务费专项资金资助(2019FZA7010)

Research progress on motor development in infants with prenatal iron deficiency

LI Ming-yan, ZHAO Zheng-yan

The Children′s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China

Received:2019-02-13 Online:2019-11-10 Published:2019-11-10
Contact: ZHAO Zheng-yan,E-mail:zhaozy@zju.edu.cn

摘要/Abstract

摘要： 铁缺乏(ID)和缺铁性贫血(IDA)是全球最常见的单一营养缺乏性疾病。孕妇和婴幼儿是ID的高危人群,孕母ID到一定程度会影响胎儿/新生儿的铁营养状况。早期ID主要通过影响髓鞘化、纹状体和多巴胺神经递质影响个体的运动发育。生后早期给予足量的铁剂治疗能纠正婴幼儿循环及组织内的ID,但无法完全逆转孕期ID所致的行为改变。深入研究孕期ID对婴幼儿运动发育的影响及其可逆性,明确铁剂治疗的关键时间窗,对提高儿童生存质量,改善远期预后具有十分重要的意义。

关键词: 铁缺乏, 髓鞘化, 多巴胺神经递质, 运动发育, 婴幼儿

Abstract: Iron deficiency (ID) and iron deficiency anemia (IDA) are the most common nutrient deficiency worldwide.Pregnant women and infants are the high-risk population of ID.Maternal ID,to a certain extent,may affect fetal/neonatal iron status.ID in early life affects motor development of individual mainly through alteration of myelination,striatal and dopamine neurotransmitter system.Early postnatal iron supplementation can correct ID in circulation and tissue,but can not completely reverse the behavioral changes caused by ID during pregnancy.Therefore,it is of great significance to further study the effect of prenatal ID and its reversibility on motor development in infancy,and to clarify the critical time window of iron therapy for improving children′s quality of life and long-term prognosis.

Key words: irondeficiency, myelination, dopamineneurotransmitter, motordevelopment, infants

中图分类号:

R174

李明燕 , 赵正言. 孕期缺铁对婴幼儿运动发育的研究进展[J]. 中国儿童保健杂志, 2019, 27(11): 1192-1195.

LI Ming-yan, ZHAO Zheng-yan. Research progress on motor development in infants with prenatal iron deficiency[J]. journal1, 2019, 27(11): 1192-1195.

参考文献

[1] World Health Organization.The global prevalence of Anemia in 2011[R].WHO Report,2015:48.
[2] 何国琳,孙鑫,谭婧,等.中国部分城市妊娠期铁缺乏和缺铁性贫血患病率的调查[J].中华妇产科杂志,2018,53(11):761-767.
[3] Zhao G,Xu G,Zhou M,et al.Prenatal iron supplementation reduces maternal anemia,iron deficiency,and iron deficiency anemia in a randomized clinical trial in rural china,but iron deficiency remains widespread in mothers and neonatesiron supplementation reduces maternal anemia,iron deficiency,and iron deficiency anemia in a randomized clinical trial in rural China,but iron deficiency remains widespread in mothers and neonates[J].J Nutr,2015,145(8):1916-1923.
[4] Cerami C.Iron nutriture of the fetus,neonate,infant,and child[J].Ann Nutr Metab,2017,71(Suppl3):8-14.
[5] FIGO Working Group on Good Clinical Practice in Maternal-Fetal Medcine.Good clinical practice advice:iron deficiency anemia in pregnancy[J].Int J Gynaecol Obstet,2019,144(3):322-324.
[6] Mireku MO,Davidson LL,Boivin MJ,et al.Prenatal iron deficiency,neonatal ferritin,and infant cognitive function[J].Pediatrics,2016,138(6).pii:e20161319.Epub 2016 Nov 17.
[7] Mccarthy EK,Kenny LC,Hourihane JOB,et al.Impact of maternal,antenatal and birth-associated factors on iron stores at birth:data from a prospective maternal-infant birth cohort[J].Eur J Clin Nutr,2017,71(6):782-787.
[8] Shao J,Lou J,Rao R,et al.Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy[J].J Nutr,2012,142(11):2004-2009.
[9] Sangkhae V,Nemeth E.Placental iron transport:the mechanism and regulatory circuits[J].Free Radic Biol Med,2019,133:254-261.
[10] Cao C,Fleming MD.The placenta:the forgotten essential organ of iron transport[J].Nutr Rev,2016,74(7):421-431.
[11] Mcardle HJ,Gambling L,Kennedy C.Iron deficiency during pregnancy:the consequences for placental function and fetal outcome[J].Proc Nutr Soc,2014,73(1):9-15.
[12] Zamora TG,Guiang SF,Widness JA,et al.Iron is prioritized to red blood cells over the brain in phlebotomized anemic newborn lambs[J].Pediatr Res,2016,79(6):922-928.
[13] Georgieff MK,Brunette KE,Tran PV.Early life nutrition and neural plasticity[J].Dev Psychopathol,2015,27(2):411-423.
[14] Lozoff B,Beard J,Connor J,et al.Long-lasting neural and behavioral effects of iron deficiency in infancy[J].Nutr Rev,2006,64(5 Pt 2):S34-43.
[15] Lou J,Mai X,Lozoff B,et al.Prenatal iron deficiency and auditory brainstem responses at 3 and 10 months:a pilot study[J].Hong Kong J Paediatr,2016,20(2):71-79.
[16]Unger EL,Bianco LE,Jones BC,et al.Low brain iron effects and reversibility on striatal dopamine dynamics[J].Exp Neurol,2014,261:462-468.
[17] Pino JMV,Da Luz MHM,Antunes HKM,et al.Iron-restricted diet affects brain ferritin levels,dopamine metabolism and cellular prion protein in a region-specific manner[J].Front Mol Neurosci,2017,10:145.
[18] Fiset C,Rioux FM,Surette ME,et al.Prenatal iron deficiency in guinea pigs increases locomotor activity but does not influence learning and memory[J].PLoS One,2015,10(7):e0133168.
[19] Felt BT,Beard JL,Schallert T,et al.Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats[J].Behav Brain Res,2006,171(2):261-270.
[20] Golub M,Hogrefe C.Prenatal iron deficiency and monoamine oxidase A (MAOA) polymorphisms:combined risk for later cognitive performance in rhesus monkeys[J].Genes Nutr,2014,9(2):381.
[21] Iglesias L,Canals J.Effects of prenatal iron status on child neurodevelopment and behavior:A systematic review[J].2018,58(10):1604-1614.
[22] Tran TD,Tran T,Simpson JA,et al.Infant motor development in rural Vietnam and intrauterine exposures to anaemia,iron deficiency and common mental disorders:a prospective community-based study[J].BMC Pregnancy Childbirth,2014,14:8.
[23] Hernandez-Martinez C,Canals J,Aranda N,et al.Effects of iron deficiency on neonatal behavior at different stages of pregnancy[J].Early Hum Dev,2011,87(3):165-169.
[24] 章逸莉,郑双双,朱柳燕,等.生命早期不同时期铁缺乏对儿童运动发育影响的纵向研究[J].中华儿科杂志,2019,57(3):194-199.
[25] Santos DCC,Angulo-Barroso RM,Li M,et al.Timing,duration,and severity of iron deficiency in early development and motor outcomes at 9 months[J].Eur J Clin Nutr,2018,72(3):332-341.
[26] Shafir T,Angulo-Barroso R,Calatroni A,et al.Effects of iron deficiency in infancy on patterns of motor development over time[J].Hum Mov Sci,2006,25(6):821-838.
[27] Chang S,Zeng L,Brouwer ID,et al.Effect of iron deficiency anemia in pregnancy on child mental development in rural China[J].Pediatrics,2013,131(3):e755-763.
[28] Angulo-Barroso RM,Li M,Santos DC,et al.Iron supplementation in pregnancy or infancy and motor development:a randomized controlled trial[J].Pediatrics,2016,137(4):pii:e20153547.
[29] Angulo-Kinzler RM,Peirano P,Lin E,et al.Spontaneous motor activity in human infants with iron-deficiency anemia[J].Early Hum Dev,2002,66(2):67-79.
[30] Berglund SK,Chmielewska A,Starnberg J,et al.Effects of iron supplementation of low-birth-weight infants on cognition and behavior at 7 years:a randomized controlled trial[J].Pediatr Res,2018,83(1-1):111-118.
[31] Rice D,Barone S.Critical periods of vulnerability for the developing nervous system:evidence from humans and animal models[J].Environ Health Perspect,2000,108(Suppl 3):511-533.
[32] Georgieff MK.Iron assessment to protect the developing brain[J].Am J Clin Nutr,2017,106(Suppl 6):1588-1593.
[33] Rao R,Ennis K,Lubach GR,et al.Metabolomic analysis of CSF indicates brain metabolic impairment precedes hematological indices of anemia in the iron-deficient infant monkey[J].Nutr Neurosci,2018,21(1):40-48.
[34] Geng F,Mai X,Zhan J,et al.Impact of fetal-neonatal iron deficiency on recognition memory at 2 months of age[J].J Pediatr,2015,167(6):1226-1232.

孕期缺铁对婴幼儿运动发育的研究进展

Research progress on motor development in infants with prenatal iron deficiency

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