关键词: 早产儿, 25-羟维生素D₃, 钙, 磷, 碱性磷酸酶, 尿素, 前白蛋白

Abstract: Objective To monitor serum 25-hydroxyvitamin D₃ [25-(OH)D₃],calcium(Ca),phosphorus (P),alkaline phosphatase (ALP),urea(UREA),prealbumin (PA) of regular and irregular follow-up model of premature infants from corrected age of 6 to 12 months after birth,so as to explore the effect of two follow-up models on nutritional status of premature infants and the safety. Methods A retrospective analysis of 143 premature infants in the Second Affiliated Hospital of Army Medical University from January 2015 to December 2017 was conducted.Totally 79 premature infants undergoing regular follow-up were assigned to group A,and 64 premature infants undergoing unscheduled follow-up were selected as group B.In the meantime,253 full-term healthy infants followed up in the pediatric care clinic were assigned to group C.Serum level of 25-(OH)D₃, Ca,ALP,P,UREA and PA were tested at the corrected age of 6 months to 12 months. Results 1) Serum 25-(OH) D₃,Ca and PA in group A and group C of premature infants were significantly higher than those in group B (P<0.05).Serum 25-(OH) D₃ in group A was significantly higher than that in group C (P<0.05).But there were no significant differences on serum ALP,P and UREA among group A,B and C.2) There were no poisoning cases of 25-(OH)D₃ in three groups.The most suitable 25-(OH)D₃ levels were found in group A and the least in group B. Conclusion 1) The incidence rates of serum 25-(OH)D₃ deficiency and hypoprealbuminemia are lower in preterm infants regularly followed up and fed according to the recommendation of child care.2) The feeding scheme for premature infants is supposed to be individualized.3) Some nutritional indicators of premature infants,such as alkaline phosphatase,lack reference criteria and need to be improved.

Key words: prematureinfants, 25-hydroxyvitaminD₃, calcium, phosphorus, alkalinephosphatase, urea, prealbumin