关键词: 哮喘, 肺功能, 细胞因子, 免疫功能

Abstract: Objective To observe the levels of FEV₁,FVC and FEV₁/FVC in children with asthma,and to analyze the correlation with cytokines and immune function. Methods A total of 100 children with asthma who were treated in the First People's Hospital of Huaian City from August 2015 to August 2018 were enrolled as asthma group,and 100 non-asthmatic children at the same period were selected as control group.The levels of FEV₁,FVC,FEV₁/FVC,cytokines and immune function of the two groups were tested,and the correlation among the levels of FEV₁,FVC,FEV₁/FVC,cytokines and immune function were analyzed. Results The levels of FEV₁,FVC,FEV₁/FVC,CD3+,CD4+ and CD8+ in asthma group were 78.47±2.13,80.23±2.76,75.68±1.05,61.09±2.43,43.15±3.0 and 21.83±2.27,respectively,significantly lower than those in control group(t=-40.376,-37.674,-56.508,-11.175,-14.530,-34.348,P<0.001).However,the levels of IL-4,IL-5 and IL-13 in asthma group were 156.63±10.14,55.26±3.45 and 57.54±4.16,respectively,which were significantly higher than those in control group(P<0.05).The levels of FEV₁,FVC and FEV₁/FVC in asthmatic children were negatively correlated with the levels of cytokines(IL-4,IL-5 and IL-13)(r=-0.552--0.358),positively related to the indexes of immune function(r=0.398—0.514). Conclusion The levels of FEV₁,FVC and FEV₁/FVC in asthmatic children are low,and closely related to cytokines and immune function.

Key words: asthma, lung function, cytokines, immune function