中国儿童保健杂志 ›› 2022, Vol. 30 ›› Issue (7): 764-769.DOI: 10.11852/zgetbjzz2021-1338

• 荟萃分析 • 上一篇    下一篇

中国儿童非酒精性脂肪性肝病患病率的Meta分析

王雨1, 杨志然1, 陈润花2   

  1. 1.北京中医药大学,北京 100029;
    2.北京中医药大学东方医院 脾胃肝胆科
  • 收稿日期:2021-08-26 修回日期:2021-10-09 发布日期:2022-07-25 出版日期:2022-07-10
  • 通讯作者: 陈润花,E-mail:excellentcrh@126.com
  • 作者简介:王雨(1994-),女,硕士研究生在读,研究方向为中医药防治消化系统疾病。
  • 基金资助:
    北京中医药大学“名医培育计划”(京中校发[2018]98号)

Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children

WANG Yu*, YANG Zhi-ran, CHEN Run-hua   

  1. *Beijing University of Chinese Medicine, Beijing 100029, China
  • Received:2021-08-26 Revised:2021-10-09 Online:2022-07-10 Published:2022-07-25
  • Contact: CHEN Run-hua, E-mail: excellentcrh@126.com

摘要: 目的 系统评价中国儿童及超重肥胖儿童非酒精性脂肪性肝病(NAFLD)患病率,为儿童及超重肥胖儿童 NAFLD 的流行病学研究和临床防治提供数据基础。方法 计算机检索中国知网、维普网、万方数据知识平台、中国生物医学文献数据库、PubMed、The Cochrane Library、EMbase、Web of Science,收集 2000-2021 年之间的关于中国儿童及超重肥胖儿童 NAFLD 患病率的中英文研究。采用R语言(version 4.0.5)对提取数据进行 Meta 分析,以随机效应模型合并数据,运用漏斗图、Egger's test、Begg's test评估偏倚风险。结果 共纳入 25项研究,其中 8 项研究为儿童NAFLD患病率,17 项研究为超重肥胖儿童 NAFLD 患病率,研究样本量总计 35 300例,其中肥胖儿童样本量为 7 649 例。Meta 分析结果显示,中国儿童 NAFLD 患病率为6.3%(95%CI:4.6%~7.9%),超重肥胖儿童 NAFLD 患病率为40.4%(95%CI:31.5%~49.9%)。亚组分析结果显示,不同性别、研究地区、研究时间的儿童及超重肥胖儿童NAFLD患病率存在差异。结论 我国儿童及超重肥胖儿童 NAFLD 患病率较高,儿童 NAFLD 正逐渐成为我国重大公共卫生问题之一。

关键词: 非酒精性脂肪性肝病, 儿童, 肥胖, 患病率, Meta分析, 中国

Abstract: Objective To systematically evaluate the prevalence of non-alcoholic fatty liver disease (NAFLD) in Chinese children and obese children, so as to provide basis for epidemiological studies and clinical prevention and treatment of NAFLD. Methods CNKI, VIP, WanFang Data, CBM, PubMed, Cochrane Library, Embase and Web of Science were searched to collect studies on the prevalence of NAFLD in Chinese children and obese children from 2000 to 2021 in home and abroad.Meta-analysis was performed using R language (version 4.0.5).Random effect model was used to merge data, funnel plot, Egger's test and Begg's test were used to evaluate the risk of bias. Results A total of 25 studies were included, including 8 studies on the prevalence of NAFLD in children, and 17 studies on the prevalence of NAFLD in obese children.The total sample size of the study was 35 300, and the sample size of obese children was 7 649.Meta-analysis showed that the prevalence of NAFLD in Chinese children was 6.3% (95%CI: 4.6% - 7.9%), and the prevalence of NAFLD in obese children was 40.4% (95%CI: 31.5% - 49.9%).Subgroup analysis showed that the prevalence of NAFLD was significantly different by gender, research areas and research time. Conclusions The prevalence of NAFLD among Chinese children and obesity children is relatively high.NAFLD in children is gradually becoming one of the major public health problems in China.

Key words: non-alcoholic fatty liver disease, children, obesity, prevalence, Meta-analysis, China

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