关键词: ACE基因, ApoE基因, 肥胖症, 血脂, 血压

Abstract: 【Objective】 To investigate the relationship between the polymorphisms for ACE gene and ApoE gene and the lipid metabolism,blood pressure in the chi1dren with simple obesity. 【Methods】 PCR-RFLP and polyacrylamide gelelectrophoresis were used to analyze the variation of the ACE gene and the ApoE gene of the 6~13 years old 105 simple obesity children(male 54 cases and female 51 cases)and the 98 healthy children(male 49 cases and female 49 cases).all children's TG,TC,HDLC,LDLC,blood pressure,height and weight were measured. 【Results】 The D-allele frequencies of ACE gene and the ε4 allele frequencies of ApoE gene in simple obesity children were higher(P<0.05).Whereas inheterozygote simp1e obesity children,the levels of the serum TG,TC,HDL-C and LDL-C,BMI,BP of the D/D and ε4 allele children were all different to the healthy children. 【Conclusions】 There are polymorphism of the ACE gene and the ApoE gene in children with obesity and health.The ACE gene and the ApoE gene have effects on lipid metabolisms,blood pressure in children with obesity and health children.

Key words: ACE gene, ApoE gene, obesity, lipid, blood pressure