68例热性惊厥患儿临床特点及其血浆甘露糖结合凝集素水平变化

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (9): 841-844.

68例热性惊厥患儿临床特点及其血浆甘露糖结合凝集素水平变化

王超前¹,华春珍^1,2,罗巧二³,王琦婧²,戴凯丽¹,黄邢邢¹,杨钦梳¹

1 杭州师范大学临床医学院,浙江杭州 310018;
2 杭州师范大学附属医院儿科,浙江杭州 310015;
3 宁波妇女儿童医院,浙江宁波 315012

收稿日期:2011-12-22 发布日期:2012-09-06 出版日期:2012-09-06
通讯作者: 华春珍,E-mail:huachunzhen@yahoo.com.cn
作者简介:王超前(1990-),女,浙江人,本科学历,主要从事儿科感染性疾病的研究
基金资助:
浙江省新苗人才计划资助项目(2010R421034)

Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion

WANG Chao-qian¹,HUA Chun-zhen^1,2,LUO Qiao-er³,WANG Qi-jing²,DAI Kai-li¹,HUANG Xing-xing¹,YANG Qin-shu¹

1 Clinical Medical School of Hangzhou Normal University,Hangzhou,Zhejiang 310018,China;
2 Department of Pediatrics,Affiliated Hospital of Hangzhou Normal University,Hangzhou,Zhejiang 310015,China;
3 Ningbo Women and Children Hospital,Ningbo,Zhejiang 315012,China

Received:2011-12-22 Online:2012-09-06 Published:2012-09-06

摘要/Abstract

摘要： 【目的】了解热性惊厥患儿的临床特点及其血浆甘露糖结合凝集素(mannose-binding lectin,MBL)水平在惊厥前后的变化。【方法】对2010年8月-2011年7月在本院住院的68例热性惊厥患儿,应用ELISA法检测急性期与恢复期血浆MBL浓度,同时进行临床特点分析。统计分析采用SPSS 11.0。【结果】急性期和恢复期MBL平均浓度分别为(595±559) ng/mL和(585±466) ng/mL,二者差异无统计学意义(Z=0.207,P=0.836),急性期与恢复期MBL水平呈线性相关(r=0.809,P<0.01)。其中恢复期MBL血浆浓度<200 ng/mL的病例占29.4%,MBL参与急性应答占全部病例的38.2%。 MBL浓度与CRP浓度无明显相关性(r =0.15,P=0.22)。89.7%的患儿热性惊厥由急性上呼吸道感染诱发,54.1%的患儿惊厥急性期CK-MB增高。【结论】惊厥应激对机体血浆MBL水平表达无明显影响。

关键词: 热性惊厥, 甘露糖结合凝集素, 血浆浓度, 临床特点, 儿童

Abstract: 【Objective】 To analyze the clinical characteristics of febrile convulsion (FC) occurred in children and study the mannose-binding lectin (MBL) levels in plasma at both acute and convalescent stages in the case group. 【Methods】 Plasma samples were separated from whole blood which was collected from children with FC at the acute and convalescent stages during August 2010 to July 2011.The MBL concentrations were measured by ELISA method and the SPSS 11.0 software was used in the study. 【Results】 Among all 68 cases,The mean MBL levels were (595±559)ng/mL at acute stage and (585±466)ng/mL in recovery stage,and no significant difference was found between the two groups (Z=0.207,P=0.836).However,there was a significant correlation of the MBL levels between the two stages (r=0.809,P<0.01).29.4% of all individuals had low MBL levels less than 200 ng/mL at convalescent stage.Acute reaction of MBL was observed in 38.2% children with FC.No correlation was found between MBL levels and CRP levels(r =0.15,P=0.22).It was found that 89.7% of the FC children was caused by acute upper respiratory tract infection.The creatine kinase-MB exceeding normal value was found in 54.1% of all individuals. 【Conclusion】 As a whole,convulsion acting as a kind of stress,had no significant effects on the MBL level in vivo.

Key words: febrile convulsion, mannose-binding lectin, plasma concentration, clinical characteristics, children

中图分类号:

R722

王超前,华春珍,罗巧二,王琦婧,戴凯丽,黄邢邢,杨钦梳. 68例热性惊厥患儿临床特点及其血浆甘露糖结合凝集素水平变化[J]. 中国儿童保健杂志, 2012, 20(9): 841-844.

WANG Chao-qian,HUA Chun-zhen,LUO Qiao-er,WANG Qi-jing,DAI Kai-li,HUANG Xing-xing,YANG Qin-shu. Analysis of clinical characteristics and plasma level of mannose-binding lectin in 68 children with febrile convulsion[J]. journal1, 2012, 20(9): 841-844.

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