脑源性神经营养因子与发育行为儿科疾病

中国儿童保健杂志 ›› 2013, Vol. 21 ›› Issue (10): 1064-1066.

脑源性神经营养因子与发育行为儿科疾病

刘秀梅综述, 李丽霞审校

青岛大学附属烟台毓璜顶医院儿科,山东烟台 264000

收稿日期:2013-01-29 发布日期:2013-10-06 出版日期:2013-10-06
通讯作者: 李丽霞,E-mail:dr_llx@sina.com
作者简介:刘秀梅(1979-),女,山东人,主治医师,博士学位,主要研究方向为发育行为儿科。
基金资助:
国家自然科学基金资助项目(81101017);山东省优秀中青年科学家科研奖励基金(BS2010F030);烟台市科学技术发展计划项目(2010148-24)

Received:2013-01-29 Online:2013-10-06 Published:2013-10-06

摘要/Abstract

摘要： 脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)是神经营养素家族的主要成员之一,与神经递质代谢、神经元重塑密切相关,BDNF在注意缺陷多动障碍、抽动障碍、学习障碍、孤独症谱系障碍等多种发育行为儿科疾病中的表达异常,BDNF基因多态性与注意缺陷多动障碍、抽动障碍有关,BDNF参与学习、记忆的过程,能够抗细胞凋亡、促进神经细胞轴突生长,与孤独症发生有关。本文就BDNF与发育行为儿科疾病的相关性做一综述。

中图分类号:

R749.94

刘秀梅综述, 李丽霞审校. 脑源性神经营养因子与发育行为儿科疾病[J]. 中国儿童保健杂志, 2013, 21(10): 1064-1066.

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