关键词: 血脂, 脂蛋白, 小于胎龄儿, 新生儿

Abstract: Objective To determine the concentrations of serum lipids and lipoprotein of small for gestational age neonates(SGA). Methods 47 SGA neonates were enrolled in this study,45 term infant of appropriate for gestational age(AGA) selected randomly were used as the control.Vein blood was collected within 12 hours after birth for biochemical analysis,including total cholesterol (TC),high-density lipoproteins cholesterols (HDL-C) low-density lipoproteins cholesterols (LDL-C),triglyceride(TG),LDL-C/HDL-C,apolipoproteins (apo)A1,apoB and apoB/apoA1.Impact of gestational age (preterm and term),degree of intrauterine growth retardation ( birth weight below the 3th percentile(SGA 1) and between the 3th and 10th percentile(SGA 2) of the local sex-specific distribution for gestational age) and gender (male and female) on the values of SGA were compared further. Results TC(2.41±0.61 vs 2.11±0.78,P<0.05)、LDL-C(0.90±0.44 vs 0.71±0.42,P<0.05)and apo-B(0.40±0.22 vs 0.29±0.15,P<0.01)concentrations,and atherogenic indices,including LDL-C/HDL-C(1.31±1.29 vs 0.82±0.46,P<0.05)and apo-B/apo-A1(0.60±0.35 vs 0.40±0.19,P<0.01)ratios,were found to be higher in the SGA compared to the control group.The SGA 1 neonates had significantly lower TC、HDL-C and apoA1 concentrations,as well as higher apo-B/apo-A1 ratio than the SGA 2 group ( P<0.01 or P<0.05).TG value was lower in preterm than in full-term SGA newborns( P<0.05).No gender difference was observed among SGA newborns. Conclusion SGA neonates displayed profiles of less favorable lipid metabolism in the early postnatal period and more severe degree of intrauterine growth retardation may be associated with higher degrees of lipid disorders,SGA has been shown to be a risk factor for developing cardiovascular disease later in life.Lower TG values in preterm SGA newborns maybe related to their fetal maturity.

Key words: lipid profiles, lipoprotein, small for gestational age, neonate