中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (2): 175-177.

• 临床研究与分析 • 上一篇    下一篇

血清维生素D水平与儿童哮喘的相关性研究

曾晶1, 闫凤2, 谢冠恩1   

  1. 1 武警广东总队医院营养科, 广东 广州 510507;
    2 广州医科大学第一附属医院营养科, 广东 广州 510120
  • 收稿日期:2013-05-02 发布日期:2014-02-10 出版日期:2014-02-10
  • 作者简介:曾晶(1974-), 女, 主治医师, 医学硕士, 主要研究方向为临床营养。

Correlation between serum vitamin D level and children suffered from asthma.

ZENG Jing1, YAN Feng2, XIE Guan-en1.   

  1. (1 Nutritional Department, Guangdong Provincial Corps Hospital of Chinese People's Armed Police Forces, Guangzhou, Guangdong 510507, China; 2 Nutritional Department, First Subsidiary Guangzhou Medical University Hospital, Guangzhou, Guangdong 510120, China)
  • Received:2013-05-02 Online:2014-02-10 Published:2014-02-10

摘要: 目的 观察哮喘儿童血清25-羟维生素D3[25-(OH)D3]浓度变化, 分析其与哮喘有关的血清总免疫球蛋白E(TIgE)含量、肺功能指标的相关性。方法 检测42例哮喘组、48例正常对照组儿童血清25-(OH)D3、TIgE含量, 以及肺功能指标, 并进行组间比较分析。结果 与正常对照组比较, 哮喘组儿童血清25-(OH)D3含量明显下降(P<0.01), 而血清TIgE含量则明显升高(P<0.01);哮喘组儿童血清25-(OH)D3与TIgE呈负相关(P<0.01), 与小气道用力呼气25%流量(MEF25)、用力呼气50%流量(MEF50)呈正相关(P<0.05)。结论 维生素D缺乏是导致儿童哮喘发作的重要原因之一, 可能与25-(OH)D3对TIgE产生抑制作用有关。

关键词: 哮喘, 25-羟维生素D3, 总免疫球蛋白E, 肺功能

Abstract: Objective To observe the changes of 25 hydroxy vitamin D3[25-(OH)D3] concentration in the serum of children with asthma, and to analyse its relationship with the content of serum total immunoglobulin E(TIgE )and lung function index associated with asthma. Methods Serum 25-(OH )D3, TIgE content and lung function index were tested in experimental group consisting of 42 patients suffered from asthma, and in control group consisting of 48 children with no asthma.Then comparisons were analyzed between the two groups. Results Compared with the normal control group, serum 25-(OH)D3 level content in experimental group consisting of children with asthma was significantly decreased (P<0.01), but the serum TIgE content increased significantly (P<0.01);serum 25-(OH)D3 level in experimental group composed of children with asthma was negatively correlated with TIgE (P<0.01), and positively correlated with forced expiratory small airway 25% flow (MEF25)and forced expiratory volume 50%(MEF50)(P<0.05). Conclusion Vitamin D deficiency is an important cause of asthma exacerbations in children, which may be related to inhibitory effect of 25-(OH)D3 on the TIgE.

Key words: children asthma, 25-hydroxy vitamin D3, total immunoglobulin E, pulmonary function

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