不同妊娠期振动对SD大鼠子代空间学习记忆的影响

doi:10.11852/zgetbjzz2014-22-09-13

中国儿童保健杂志 ›› 2014, Vol. 22 ›› Issue (9): 938-942.DOI: 10.11852/zgetbjzz2014-22-09-13

不同妊娠期振动对SD大鼠子代空间学习记忆的影响

赵萍, 杨柳, 陈超, 曾晓雯, 张玲, 冼丹霞, 金宇

中山大学公共卫生学院妇幼卫生学系, 广东广州 510080

收稿日期:2014-01-03 发布日期:2014-09-10 出版日期:2014-09-10
通讯作者: 金宇,E-mail:jinyu@mail.sysu.edu.cn
作者简介:赵萍(1987-), 女, 陕西人, 硕士研究生, 主要研究方向为临床儿童心理诊疗。
基金资助:
广东省大学生创新训练项目(1055812297); 中山大学医科2012年学生业余科研项目(中大医教〔2012〕29号,No.49); 中山大学实验室开放基金(中大设备[2013]6号,No.KF201310); 2013年中山大学学生暑期科研项目(中大医教[2013]62号,No.36)

Effects of different prenatal vibration stress on spatial learning and memory in rats

ZHAO Ping, YANG Liu, CHEN Chao, ZENG Xiao-wen, ZHANG Ling, XIAN Dan-xia, JIN Yu

Public Health School of Sun Yat-sen University,Guangzhou,Guangdong 510080,China

Received:2014-01-03 Online:2014-09-10 Published:2014-09-10
Contact: JIN Yu,E-mail:jinyu@mail.sysu.edu.cn

摘要/Abstract

摘要： 目的探讨不同妊娠期振动对大鼠子代空间学习记忆的影响。方法分别在SD大鼠妊娠的1~7 d、8~14 d、15~21 d施加强弱交替的振动刺激,在子鼠60 d使用Barnes 迷宫测试其空间学习记忆能力,比较各组间空间学习记忆的差异。结果学习过程:1)探索路程:妊娠早期振动组在第4天,妊娠中期在第1天,妊娠晚期在第1天高于对照组,妊娠晚期在第2、3天低于对照组(P＜0.05);2)探索平均速度:妊娠早期在第2天,妊娠中期在第1、2天,妊娠晚期在第1、2、3、7、8天均低于对照组(P＜0.05);3)错误探索时间:妊娠早期在第1、3、4、7、8天,妊娠中期在第3、4、5、8天高于对照组,妊娠晚期在第2、6天低于对照组(P＜0.05);4)首次探索目标洞潜伏期:妊娠中期在第5天高于对照组(P＜0.05)。记忆过程:妊娠早期振动组的错误探索时间明显高于对照组(Mann-Whitney U=43.00,P=0.000),妊娠晚期振动组的探索路程(Mann-Whitney U=150.00)、平均速度(Mann-Whitney U=150.00)和错误探索时间(Mann-Whitney U=164.50)明显低于对照组(P<0.05或<0.01)。结论妊娠早期振动损害子代的空间学习记忆能力,妊娠晚期振动可能促进子代的空间学习记忆能力,而妊娠中期仅损害子代的空间学习能力。

关键词: 妊娠期振动, Barnes迷宫, 空间学习记忆能力

Abstract: Objective To explore the effects of prenatal vibration stress in different gestational time points on the spatial learning and memory in rats. Methods The Sprague-Dawley (SD) pregnant rats were vibrated strong and weak alternately in 1~7 d,8~14 d,15~21 d of gestation period,and the offspring was tested in Barnes maze to identify their spatial learning and memory,the difference of each group then compared. Results Learning process:1)The journey of exploration:It was higher than control group during early pregnancy group was in 4 d,during middle pregnancy group in 1d and during late pregnancy group in 1d;It was lower than control group during late pregnancy group in 2 and 3 d (P＜0.05);2)The average speed of exploration:It was lower than control group during early pregnancy group in 2 d,during middle pregnancy group in 1 d and 2 d,during late pregnancy group in 1,2,3,7,8 d (P＜0.05);3)The time of exploring errors holes:It was higher than control group during early pregnancy group in 1,2,4,7,8 d,during middle pregnancy group in 3,4,5,8d;It was lower than control group during late pregnancy group in 2,6 d (P＜0.05);4)The latency of exploring target hole:It was higher than control group during middle pregnancy group in 5 d (P＜0.05).Memory process:The time of exploring errors holes was higher during early pregnancy group(Mann-Whitney U=43.00,P=0.000);The journey of exploration (Mann-Whitney U=150.00),the average speed of exploring (Mann-Whitney U=150.00) and the time of exploring errors holes (Mann-Whitney U=164.50) were lower during late pregnancy group(P<0.05 or <0.01). Conclusion The vibration stress in early pregnancy group may damage the spatial learning and memory ability,and it may promote the spatial learning and memory ability in the late pregnancy group; but the vibration stress in mid pregnancy group only damage the spatial learning ability.

Key words: prenatal vibration stress, Barnes maze, spatial learning and memory

中图分类号:

R749.94

赵萍, 杨柳, 陈超, 曾晓雯, 张玲, 冼丹霞, 金宇. 不同妊娠期振动对SD大鼠子代空间学习记忆的影响[J]. 中国儿童保健杂志, 2014, 22(9): 938-942.

ZHAO Ping, YANG Liu, CHEN Chao, ZENG Xiao-wen, ZHANG Ling, XIAN Dan-xia, JIN Yu. Effects of different prenatal vibration stress on spatial learning and memory in rats[J]. journal1, 2014, 22(9): 938-942.

参考文献

[1] 林崇德,杨志良,黄希庭.心理学大辞典[M].上海教育出版社,2004:1575.
[2] Buss C,Davis EP,Hobel CJ,et al.Maternal pregnancy-specific anxiety is associated with child executive function at 6~9 years age[J].Stress,2011,14(6):665-676.
[3] Emack J,Kostaki A,Walker CD,et al.Chronic maternal stress affects growth,behaviour and hypothalamo-pituitary-adrenal function in juvenile offspring[J].Hormones andBehavior,2008,54(4):514-520.
[4] Wilson CA,Terry AV Jr.Variable maternal stress in rats alters locomotor activity,social behavior,and recognition memory in the adult offspring[J].Pharmacol Biochem Behav,2013,104:47-61.
[5] 童建斌,刘丹,黄菊芳,等,不同时期的母鼠妊娠期应激对子代成年后海马的影响[J].中国现代医学杂志,2004,14(11):81-83.
[6] Schwabe L,Bohbot VD,Wolf OT.Prenatal stress changes learning strategies in adulthood[J].Hippocampus,2012,22(11):2136-2143.
[7] Kapoor A,Kostaki A,Janus C,et al.The effects of prenatal stress on learning in adult offspring is dependent on the timing of the stressor[J].Behav Brain Res,2009,197(1):144-149.
[8] Sahu SS,Madhyastha S,Rao GM.Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na(+),K(+)-ATPase activity[J].Pharmacol Biochem Behav,2013,103(3):520-525.
[9] 张先庚,杨宇琦,李世通,等.模拟地震实验深化“恐伤肾”的研究[J].四川中医,2008,26(12):27-28.
[10] Li X,Risbrough VB,Cates-Gatto C,et al.Comparison of the effects of the GABAB receptor positive modulator BHF177 and the GABAB receptor agonist baclofen on anxiety-like behavior,learning,and memory in mice[J].Neuropharmacology,2013,70:156-167.
[11] Schwabe L,Wolf OT,Oitzl MS.Memory formation under stress:Quantity and quality[J].Neurosci Biobehav,2010,34(4):584-591.
[12] 毛凤霞,姚梅玲,产前束缚应激对大鼠子代的影响[J].中国妇幼保健,2008,23(26):3720-3721.
[13] Yang J,Han H,Cao J,et al.Prenatal stress modifies hippocampal synaptic plasticity and spatial learning in young rat offspring[J].Hippocampus,2006,16(5):431-436.

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不同妊娠期振动对SD大鼠子代空间学习记忆的影响

Effects of different prenatal vibration stress on spatial learning and memory in rats

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