关键词: 胼胝体, 大脑, 早产儿, 胎龄, 磁共振成像

Abstract: Objective To compare the difference between full-term infant and very low birth weight (VLBW) premature infant at term equivalent for the area,eccentricity ratio and skew of neonatal corpus callosum and to provide references for early evaluation the development of premature infant brain. Methods Brain MR images of 55 full-term infants with gestational age 40 weeks were obtained,which were collected in 24 h after birth.And brain MR images of 80 VLBW neonates at 40 weeks' gestational age equivalent were successfully obtained.Routine T1WI,T2WI and DWI were applied.T1-weighted images on the mid-sagittal slice were selected,analyzed and measured.127 eligible MR images of them were chosen,49 cases in the full-term infant group,78 cases in the premature infant group.And then,corpus callosum and brain in the MR images were sketched two times by two radiographic doctors at different times,all data were analyzed by Image Processing Function of MATLAB R2010a,and then the area,eccentricity ratio,anterior skew and posterior skew of neonatal corpus callosum were obtained. Results The area and posterior skew of corpus callosum in premature infant group were smaller than those in full-term infant group,and the anterior skew of corpus callosum in full-term infant group was smaller than that in premature infant group,the differences were statistically significant (all P<0.05).The eccentricity ratio of corpus callosum in premature infant group was smaller than that in full-term infant group,but the difference between the two groups as not statistically significant (P>0.05). Conclusions The development of premature infant corpus callosum is affected by prematurity,the size and shape of the corpus callosum differed between full-term infants and VLBW premature infants at term equivalent age.The corpus callosum was smaller and more circular in VLBW premature infants.

Key words: corpus callosum, brain, premature infant, gestational age, magnetic resonance imaging