血清内脂素与儿童初诊1型糖尿病及合并酮症酸中毒患儿糖脂代谢的相关性研究

doi:10.11852/zgetbjzz2016-24-04-05

中国儿童保健杂志 ›› 2016, Vol. 24 ›› Issue (4): 355-358.DOI: 10.11852/zgetbjzz2016-24-04-05

血清内脂素与儿童初诊1型糖尿病及合并酮症酸中毒患儿糖脂代谢的相关性研究

徐哲¹,张红军²,李海军³,任静³,刘亚军¹

四川省广元市中心医院1 儿科;
2 内分泌科;
3 检验科,四川广元 628000

收稿日期:2015-08-25 发布日期:2016-04-10 出版日期:2016-04-10
通讯作者: 张红军,E-mail2571754696@qq.com
作者简介:徐哲(1971-),男,江苏人,主任医师,主要研究方向为儿童哮喘,糖尿病诊治和管理。
基金资助:
2015年广元市科技局科技计划立项项目(15KJZCZC003)

Correlation between serum visfatin and glucolipid metabolism in children with newly diagnosed type 1 diabetes mellitus and children with that combined with ketoacidosis.

XU Zhe¹,ZHANG Hong-jun²,LI Hai-jun³,REN Jing³,LIU Ya-jun¹.

1 Department of Pediatrics;
2 Department of Endocrinology;
3 Department of Laboratory,Guangyuan Center Hospital,Guangyuan,Sichuan 628000,China

Received:2015-08-25 Online:2016-04-10 Published:2016-04-10
Contact: ZHANG Hong-jun,E-mail2571754696@qq.com

摘要/Abstract

摘要： 目的通过检测1型糖尿病(T1DM)患儿及T1DM合并酮症酸中毒患儿血清内脂素(visfatin)水平,探讨血清visfatin与T1DM及酮症酸中毒患儿的糖脂代谢及胰岛β细胞功能的相关性。方法选取2010年6月-2014年6月于广元市中心医院门诊就诊和住院的1型糖尿病患儿82例,正常对照组31例,1型糖尿病患儿分为初诊T1DM组(T1DM I组) 61例,T1DM合并酮症酸中毒组(T1DM Ⅱ组) 21 例。比较三组血清visfatin水平、空腹血糖(FPG)、空腹胰岛素(Fins)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、游离脂肪酸(FFA)及糖化血红蛋白(HbAlc),体质指数(BMI)及腰臀比(WHR)。并进行T1DM I组和T1DM Ⅱ组的血清visfatin与其他监测指标的单因素相关性分析,及血清visfatin与其相关因素的多元线性逐步回归分析。结果 1)儿童T1DM I组血清visfatin水平明显低于正常对照组(P<0.01),T1DM Ⅱ组血清visfatin水平较T1DM I组明显降低(P<0.01)。2)采用Pearson 相关分析,在T1DM I组和T1DM Ⅱ组中血清visfatin均与BMI、WHR、HDL-C、Fins、Homa-β呈正相关,均与TC、TG、LDL-C、FFA、FPG、HbAlc呈负相关。多元线性逐步回归分析显示,T1DM I组和 T1DM Ⅱ组的WHR、FFA、FPG、Homa-β进入回归方程,WHR、FFA、FPG、Homa-β是影响血清visfatin水平的独立危险因素。结论 1型糖尿病及合并酮症酸中毒患儿血清visfatin水平较正常组明显降低,可能与内脏脂肪含量减少,糖脂代谢紊乱及胰岛β细胞功能损害有关。

关键词: 1型糖尿病, 糖尿病酮症酸中毒, 糖脂代谢, 胰岛β细胞功能

Abstract: Objective To observe serum visfatin level in children with type 1 diabetes mellitus (T1DM) and children with T1DM combined with ketoacidosis and investigate the correlation between serum visfatin level and glucolipid metabolism and islet β-cell function of these children. Methods From June 2010 to June 2014,82 children with T1DM who visited doctors in the Outpatient Department and hospitalized in Guangyuan Center Hospital,and 31 healthy controls were enrolled.Children with only newly diagnosed T1DM were assigned into T1DM I group (n=61),and children with T1DM combined with ketoacidosis were assigned into T1DM Ⅱ group (n=21).Comparisons were analyzed made in serum visfatin level,FPG,Fins,TC,TG,HDL-C,LDL-C,FFA,HbAlc,BMI and WHR among the three groups.Single-factor correlation analysis was conducted between serum visfatin level and other monitoring indexes of T1DM I group and T1DM Ⅱ group,and multivariate regression analysis of the correlation between serum visfatin level and other relevant factors was also conducted. Results 1)T1DMI group was lower than normal control group in serum visfatin level(P<0.01),and T1DM Ⅱ group was lower than T1DM I group in serum visfatin level (P<0.01).2)Pearson correlation analysis showed that the serum visfatin levels of T1DM I group and T1DM Ⅱ group were positively correlated with BMI,WHR,HDL-C,Fins,Homa-β,and were negatively correlated with TC,TG,LDL-C,FFA,FPG and HbAlc.Multivariate linear regression analysis showed that WHR,FFA,FPG and Homa-β of T1DM I group and T1DM Ⅱ group entered regression equation,which indicated that WHR,FFA,FPG and Homa-β were independent risk factors for serum visfatin level. Conclusion Children with T1DM and children with T1DM combined with ketoacidosis are lower than healthy controls in serum visfatin level,which may be related with the reduction of the fat content in viscera,glucose and lipid metabolism disorder and dysfunction of islet β-cell.

Key words: type 1 diabetes mellitus, diabetic ketoacidosis, glucolipid metabolism, islet β-cell function

中图分类号:

R179

徐哲,张红军,李海军,任静,刘亚军. 血清内脂素与儿童初诊1型糖尿病及合并酮症酸中毒患儿糖脂代谢的相关性研究[J]. 中国儿童保健杂志, 2016, 24(4): 355-358.

XU Zhe,ZHANG Hong-jun,LI Hai-jun,REN Jing,LIU Ya-jun.. Correlation between serum visfatin and glucolipid metabolism in children with newly diagnosed type 1 diabetes mellitus and children with that combined with ketoacidosis.[J]. journal1, 2016, 24(4): 355-358.

参考文献

[1] Yan S,zhang B.The espanding hurden of cantionnabolie risk in hina:the China hralth and nutrition survery[J].Ohesicy Reviews,2012,13(9):810-821.
[2] Maahs DM,West NA,Lawrence JM,et al.Epidemiology of type 1 diabetes[J].Endocrinol Metab Clin North Am,2010,39(3):481-497.
[3] 季荔,杨涛.治愈1型糖尿病离我们有多远?[J].糖尿病天地:临床,2015,9(1):52-56.
[4] Brownj EP,Onyango DJ,Ramanjaneya M,et al.Visfatin regulates insulin secretion,insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic p-cells[J].J Mol Endocrinol,2010,44(3):171-178.
[5] Revollo JR,Krner A,Mills KF,et al.Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme[J].Cell Metab,2007,6(5):363-375.
[6] 程群,彭永德,董维平,等.Visfatin通过线粒体途径抑制胰岛β细胞凋亡[J].上海交通大学学报:医学版,2009,29(8):922-925.
[7] 胡亚美,江载芳.诸福棠实用儿科学[M].7版.北京:人民卫生出版社,2002:2042-2043.
[8] 巩纯秀,杨秋兰.《中华医学会儿科学分会内分泌遗传代谢学组儿童糖尿病酮症酸中毒诊疗指南》(2009年版)解读[J].中国实用儿科杂志,2010,25(11):850-853.
[9] Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin:a protein secreted by visceral fat that mimics the effects of insulin[J].Science,2005,307(578):426-430.
[10] Toruner F,Altinova AE,Bukan N,et al.Plasma visfatin concentrations in subjects with type 1 diabetes mellitus[J].Horm Res,2009,72(1):33-37.
[11] Alexiadou K,Kokkinos A,Liatis SA,et al.Differences in plasma apelin and visfatin levels between patients with type 1 diabetes mellitus and healthy subjects and response after acute hyperglycemia and insulin administration[J].Hormones-International Journal of Endocrinology and Metabolism,2012,11(4):444-450.
[12] Bermejo AL,Julia BC,Balsells MF,et al.Serum visfatin increases with progressive beta-cell deterioration[J].Diabetes,2006,55(10):2871-2875.
[13] Haider DG,Pleiner J,Francesconi M,et al.Exercise training lowers plasma visfatin concentrations in patients with type 1 diabetes[J].J Clin Endocrinol Metab,2006,91(11):4702-4704.
[14] Song HK,Lee MH,Kim BK,et al.Visfatin:a new player[J].in mesangial cell physiology and diabetic nephropathy[J].Am J Physiol Renal Physiol,2008,295(5):F1485.
[15] 蒲云飞,何洪波,赵志钢,等.腹型肥胖内脏脂肪定量检测的评估及其临床意义[J].中华医学杂志,2008,88(34):2391-2394.
[16] Kitabchi AE,Umpierrez GE,Murphy MB,et al.American diabetes association.hypergly-cemic crises in diabetes[J].Diabetes Care,2004,27(Suppl 1):94-102.
[17] Mcevilly A,Kirk J.Twenty years of a multidisciplinary paediatric diabetes home care unit[J].Arch Dis Child,2005,90(4):342-345.
[18] 王秀敏,梁黎,董关萍,等.浙江省1999~2004年新诊断儿童1型糖尿病流行病学特征及血脂水平[J].实用儿科临床杂志,2006,21(8):471-472,482.
[19] Li J,Meng F,Song C,et al.Characterization of chicken visfatin gene:cDNA cloning,tissue distribution,and promoter analysis[J].Poult Sci,2012,91(11):2885-2894.
[20] 樊立娜,刘素筠.内脂素--糖尿病治疗的新靶点[J].医学研究杂志,2009,38(1):7-9,19.

血清内脂素与儿童初诊1型糖尿病及合并酮症酸中毒患儿糖脂代谢的相关性研究

Correlation between serum visfatin and glucolipid metabolism in children with newly diagnosed type 1 diabetes mellitus and children with that combined with ketoacidosis.

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 11

编辑推荐

Metrics

[1]	焦丽华, 厉红, 刘建丽. 血浆促肾上腺皮质激素、皮质醇水平与1型糖尿病患儿糖化血红蛋白水平的相关性研究[J]. 中国儿童保健杂志, 2021, 29(4): 377-380.
[2]	常洁, 顾芳, 王杰英, 李荣敏, 雷淑琴, 李珍. 初发1型糖尿病患儿的血脂情况及与糖化血红蛋白水平的关系研究[J]. 中国儿童保健杂志, 2020, 28(8): 909-911.
[3]	周焕珍, 杨柳, 王爱萍, 杨洋, 张红红. 1型糖尿病儿童肠道菌群谱分析研究[J]. 中国儿童保健杂志, 2020, 28(10): 1083-1087.
[4]	林丽娜, 李倩婷, 林娟, 江平湖, 黄宏. 1型糖尿病患儿父亲参与教养的现状及其与患儿生存质量的相关性分析[J]. 中国儿童保健杂志, 2020, 28(1): 104-107.
[5]	吴巧玲, 余文, 龚春丹, 张丹, 赵正言, 彭咏梅. 出生体重与婴幼儿体格发育及糖脂代谢的相关性分析[J]. 中国儿童保健杂志, 2019, 27(7): 724-728.
[6]	缪艳霞, 王芳, 乔良美, 刘怡欣, 常黎华. 学龄期1型糖尿病儿童生存质量差异的因素分析[J]. 中国儿童保健杂志, 2019, 27(5): 551-554.
[7]	赵永鑫, 辛颖. 1型糖尿病儿童氧化应激水平的研究[J]. 中国儿童保健杂志, 2017, 25(7): 675-678.
[8]	宋海晓, 董肖萍, 陈志红, 衣明纪, 李堂, 刘静. 青岛地区1型糖尿病儿童及青少年血糖管理状况和生存质量的调查研究[J]. 中国儿童保健杂志, 2017, 25(5): 459-462.
[9]	张丙金,王蓓蓓,张志明,赵连礼. 基于互联网形式的群组看病及同伴教育在1型糖尿病患儿中的应用[J]. 中国儿童保健杂志, 2015, 23(12): 1300-1302.
[10]	蒋雪综述, 李晓南审校. 人乳中脂代谢调控因子的发现,功能和临床意义[J]. 中国儿童保健杂志, 2013, 21(5): 502-504.
[11]	陈永兴,卫海燕,李春枝,张英娴,王会贞,刘晓景,刘芳. 1型糖尿病患儿血清维生素A浓度变化及其与Th1/Th2平衡相关性[J]. 中国儿童保健杂志, 2012, 20(5): 404-405.