关键词: 重组人生长激素, 生长激素缺乏症, 甲状腺功能, 儿童

Abstract: Objective To explore the short-term effect of China-made recombinant human growth hormone (rhGH) administration on thyroid function in children with growth hormone deficiency (GHD) and its clinical significance. Methods Totally 72 euthyroid children of GHD underwent rhGH replacement therapy.Serum FT3,FT4,TSH were separately assessed before and after 3,6 months of treatment.The height and body mass were measured by the same measuring tool,and then the growth velocity (GV) and the height standard deviation score (HtSDS) were calculated.The changes of thyroid hormone levels and its correlation with clinical index were observed before and after treatment. Results 1) The levels of FT3 and FT3/FT4 ratios both showed statistically significant increases at 3 and 6 months after treatment (P＜0.05),however,compared with before treatment,the differences of FT4 and TSH levels were both not statistically significant (P＞0.05).2) At 3 and 6 months after treatment,Ht,HtSDS,GV were significantly higher than those of before treatment (P＜0.001).3) The entire level of FT3 and FT3/FT4 ratios were both positively correlated with GV and HtSDS before and after treatment (P＜0.05). Conclusion The rhGH administration affects the peripheral thyroid hormone metabolism,and the increase of serum FT3 level may contribute to the growth of GHD children.

Key words: recombinant human growth hormone, growth hormone deficiency, thyroid function, children