关键词: 早产, 未足月胎膜早破, 白介素-6, 肿瘤坏死因-α, 绒毛膜炎

Abstract: Objective To investigate relationship between IL-6 and TNF-α in umbilical cord blood of neonates with preterm premature rupture of membranes (PPROM) and chioroamnionitis. Methods Totally 45 cases of pregnant women with premature rupture of membranes in obstetric department of Affiliated Hospital of Yanbian University were enrolled as observation group from September 2016 to January 2017,who were with singleton,head position,gestational age of 28~37 w and production process launched within 12 hours after rupture of membranes.While 45 cases of pregnant women with full pregnancy were enrolled as control group in the same period,and the production times of pregnant women were 0~1.And 5 ml umbilical cord blood were taken after cutting the neonatal umbilical cord.The levels of IL-6 and TNF-α in cord blood of newborn infants were measured by flow cytometry.At the same time,placenta and fetal membrane tissues of the pregnant women with PPROM were send to pathological examination,in order to diagnose chorionic inflammation. Results There were no significantly statistical differences on the levels of IL-6 and TNF-α in umbilical cord blood of newborn infants between observation group and control group(P>0.05);There were significantly statistical differences in the levels of IL-6 and TNF-α in umbilical cord blood between pregnant women with or without chioroamnionitis(P<0.05). Conclusion Increasing levels of IL-6 and TNF-α in umbilical cord blood of neonates with PPROM are associated with choriocarcinoma.

Key words: premature delivery, preterm premature rupture of membranes, tumor necrosis factor-α, interleukin-6, chorioamnionitis