关键词: 单纯乳房早发育, 特发性中枢性性早熟, 危险因素, 女童

Abstract: Objective To investigate the risk factors for isolated premature thelarche (IPT) and idiopathic central precocious puberty (ICPP) of girls in Tianjin. Methods A total of 110 cases of simple early breast development and 127 cases of girls with idiopathic central precocious puberty in the Affiliated Hospital of Logistic University of PAP Hospital were selected from February 2016 to May 2017,1∶2 pairs were matched according to age,and 220 normal girls and 254 normal controls were selected as controls,questionnaire survey was conducted among all subjects. Results Logistic regression analysis showed that pollution factory near the address,mother's menarche age ≤13 years old,frequency of use of plastic products,animal food or high protein diet and pigment food containing preservatives were risk factors for IPT (OR=9.061,22.220,2.980,6.508 and 14.069,P＜0.05);Taking nutrition supplements,using adult wash skin care products,food containing hormones,mother's menarche age ≤13 years old and seafood diet were risk factors for ICPP (OR=3.071,2.445,4.063,2.809 and 2.849,P＜0.05). Conclusion The risk factors of IPT and ICPP in girls in Tianjin city are complex,which are related to maternal age at menarche,diet habits and so on.

Key words: isolated premature thelarche, idiopathic central precocious puberty, risk factors, girls