邻苯二甲酸酯与儿童注意缺陷多动障碍关联的研究进展

doi:10.11852/zgetbjzz2018-26-05-15

摘要/Abstract

摘要： 随着环境问题日益严重,环境污染物对儿童神经心理行为发育的影响成为社会关注的热点问题。注意缺陷多动障碍(ADHD)是儿童期最普遍、最常见的心理与行为障碍之一,环境毒物对于儿童ADHD症状、疾病存在一定的贡献。越来越多的毒理学和流行病学证据表明,邻苯二甲酸酯(PAEs)与儿童ADHD症状、疾病可能存在关联,二者间的关联可能涉及到多巴胺神经元系统、甲状腺系统、氧化应激及睾酮修饰的异常。明确PAEs与儿童ADHD的关联及内在机制,对于深入探索ADHD病因学和病理机制至关重要。

关键词: 注意缺陷多动障碍, 邻苯二甲酸酯, 儿童

Abstract: With the increasing deterioration of environment problems, the impact of environmental toxicants on the development of children′s neuropsychological behavior has become a hot social issue. Attention deficit hyperactivity disorder (ADHD) is one of the most common mental and behavioral disorders in childhood, and environmental toxicants may contribute to child ADHD symptoms and disease. Increasing toxicological and epidemiological evidence suggests that there may be associations between phthalates (PAEs) and children′s ADHD symptoms and disease. The potential mechanisms may involve dopamine neuronal, thyroid system, oxidative stress and testosterone modification abnormalities. It is essential to understand the correlation and potential mechanisms between PAEs and ADHD in children for further etiology and pathogenesis study.

Key words: attention deficit hyperactivity disorder, Phthalates, children

中图分类号:

R179

胡丹, 何绘敏, 孙瑾, 肖绪武. 邻苯二甲酸酯与儿童注意缺陷多动障碍关联的研究进展[J]. 中国儿童保健杂志, 2018, 26(5): 518-520.

HU Dan, HE Hui-min, SUN Jin, XIAO Xu-wu. Research progress on the association of phthalates with children attention deficit hyperactivity disorder[J]. journal1, 2018, 26(5): 518-520.

参考文献

[1] Akinbami LJ, Liu X, Pastor PN , et al.Attention deficit hyperactivity disorder among children aged 5~17 years in the United States, 1998-2009 [J]. NCHS Data Brief, 2011,70: 1-8.
[2] Wang T, Liu K, Li Z , et al.Prevalence of attention deficit/hyperactivity disorder among children and adolescents in China: a systematic review and meta-analysis [J]. BMC Psychiatry, 2017, 17(1): 32.
[3] Christakis DA. Rethinking attention-deficit/hyperactivity disorder [J]. JAMA Pediatr, 2016, 170(2): 109-110.
[4] Ma TT, Wu LH, Chen L , et al.Phthalate esters contamination in soils and vegetables of plastic film greenhouses of suburb Nanjing, China and the potential human health risk [J]. Environ Sci Pollut Res Int, 2015, 22(16): 12018-12028.
[5] Wormuth M, Scheringer M, Vollenweider M, et al.What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? [J]. Risk Anal, 2006, 26(3): 803-824.
[6] Zhang Y, Cao Y, Shi H , et al.Could exposure to phthalates speed up or delay pubertal onset and development? A 1.5-year follow-up of a school-based population [J]. Environ Int, 2015, 83: 41-49.
[7] Hartmann C, Uhl M, Weiss S , et al.Human biomonitoring of phthalate exposure in Austrian children and adults and cumulative risk assessment [J]. Int J Hyg Environ Health, 2015, 218(5): 489-499.
[8] Li Y, Zhuang M, Li T , et al.Neurobehavioral toxicity study of dibutyl phthalate on rats following in utero and lactational exposure [J]. J Appl Toxicol, 2009, 29(7): 603-611.
[9] Chen T, Yang W, Li Y , et al.Mono-(2-ethylhexyl) phthalate impairs neurodevelopment: inhibition of proliferation and promotion of differentiation in PC12 cells [J]. Toxicol Lett, 2011, 201(1): 34-41.
[10] Holahan MR, Smith CA. Phthalates and neurotoxic effects on hippocampal network plasticity [J]. Neurotoxicology, 2015, 48: 21-34.
[11] Smith CA, Macdonald A, Holahan MR. Acute postnatal exposure to di(2-ethylhexyl) phthalate adversely impacts hippocampal development in the male rat [J]. Neuroscience, 2011, 193: 100-108.
[12] Masuo Y, Ishido M, Morita M , et al.Effects of neonatal treatment with 6-hydroxydopamine and endocrine disruptors on motor activity and gene expression in rats [J]. Neural Plast, 2004, 11(1-2): 59-76.
[13] Kim BN, Cho SC, Kim Y , et al.Phthalates exposure and attention-deficit/hyperactivity disorder in school-age children [J]. Biological Psychiatry, 2009, 66(10): 958-963.
[14] Chopra V, Harley K, Lahiff M , et al.Association between phthalates and attention deficit disorder and learning disability in US children, 6-15 years [J]. Environmental Research, 2014, 128: 64-69.
[15] Park S, Lee JM, Kim JW , et al.Association between phthalates and externalizing behaviors and cortical thickness in children with attention deficit hyperactivity disorder [J]. Psychological Medicine, 2015, 45(8): 1601-1612.
[16] Hu D, Wang YX, Chen WJ, et al.Associations of phthalates exposure with attention deficits hyperactivity disorder: A case-control study among Chinese children [J]. Environ Pollut, 2017, 229: 375-385.
[17] Wang R, Xu X and Zhu Q. Pubertal exposure to di-(2-ethylhexyl) phthalate influences social behavior and dopamine receptor D2 of adult female mice [J]. Chemosphere, 2016, 144: 1771-1779.
[18] Pathak A, Sinha RA, Mohan V , et al.Maternal thyroid hormone before the onset of fetal thyroid function regulates reelin and downstream signaling cascade affecting neocortical neuronal migration [J]. Cereb Cortex, 2011, 21(1): 11-21.
[19] Berbel P, Mestre JL, Santamaria A , et al.Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation [J]. Thyroid, 2009, 19(5): 511-519.
[20] Vermiglio F, Lo Presti VP, Moleti M , et al.Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries [J]. J Clin Endocrinol Metab, 2004, 89(12): 6054-6060.
[21] Johns LE, Ferguson KK, McElrath TF , et al.Associations between repeated measures of maternal urinary phthalate metabolites and thyroid hormone parameters during pregnancy [J]. Environ Health Perspect, 2016,124(11):1808-1815.
[22] Breous E, Wenzel A and Loos U. The promoter of the human sodium/iodide symporter responds to certain phthalate plasticisers [J]. Mol Cell Endocrinol, 2005, 244(1-2): 75-78.
[23] Ghisari M, Bonefeld-Jorgensen EC. Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions [J]. Toxicol Lett, 2009, 189(1): 67-77.
[24] Ferguson KK, McElrath TF, Chen YH, et al.Urinary phthalate metabolites and biomarkers of oxidative stress in pregnant women: a repeated measures analysis [J]. Environ Health Perspect, 2015, 123(3): 210-216.
[25] Lin CH, Chen TJ, Chen SS , et al.Activation of Trim17 by PPARγ is involved in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2α cells [J]. Toxicol Lett, 2011, 206(3): 245-251.
[26] Xu Y, Agrawal S, Cook TJ , et al.Di-(2-ethylhexyl)-phthalate affects lipid profiling in fetal rat brain upon maternal exposure [J]. Arch Toxicol, 2007, 81(1): 57-62.
[27] Howdeshell KL, Wilson VS, Furr J , et al.A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner [J]. Toxicol Sci, 2008, 105(1): 153-165.
[28] Swan SH. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans [J]. Environ Res, 2008, 108(2): 177-184.
[29] Wang YX, You L, Zeng Q , et al.Phthalate exposure and human semen quality: results from an infertility clinic in China [J]. Environ Res, 2015, 142: 1-9.