关键词: 社会交往能力, 儿童, 孤独症谱系障碍, 鼻喷催产素治疗

Abstract: Objective To explore the role of nasal spray oxytocin therapy for the social interaction of children with autism spectrum disorder (ASD),in order to find new approaches for the treatment of ASD children. Methods A prospective case-control study was conducted. Totally 25 ASD children were enrolled in this study and were randomly divided into treatment group (n=12) and control group (n=13).The treatment group was treated with nasal spray oxytocin therapy,while the control group only received basic treatment. Results 1) There was no significant difference on serum oxytocin level between treatment group and control group before treatment(t=0.09,P>0.05). The serum oxytocin levels in the treatment group were significantly higher than those in control group in the fourth week during treatment and one month after treatment (t=7.41,6.23,P<0.05). 2) There was no significant difference on Social Responsive Scale (SRS) between treatment group and control group before treatment,while the difference was significant in the fourth week during treatment(t=3.87,P<0.05). However,no significant differences on the score of Chinese Version of Pycho-Educational Profile-3rd edition (CPEP-3) were found before treatment,in the fourth week during treatment and after treatment(P>0.05). Conclusions ASD children in nasal spray oxytocin therapy can improve the oxytocin levels in the blood of ASD children and reduce the scores of social intercourse ability scale. So it is promising in the rehabilitation of children with ASD.

Key words: autistic spectrum disorder, nasal spray oxytocin therapy, social interaction, children