关键词: 哮喘, 半胱胺酰白三烯, 单核细胞趋化蛋白-4, 巨噬细胞衍生趋化因子

Abstract: Objective To investigate the levels of cysteinyl leukotrienes(Cys LTs),monocyte chemoattractant protein-4(MCP-4) and macrophage-derived chemokine(MDC) in peripheral blood of asthma children,in order to explore their value in clinical assessment of asthma. Methods Totally 220 children were enrolled in this study from June 2016 to June 2018,including 48 cases in asthma attack group,52 cases in asthma remission period,64 pneumonia children and 56 healthy children.Serum levels of Cys LTs,MCP-4 and MDC in each group were compared. Results Serum levels of Cys LTs,MCP-4 and MDC in acute stage of asthma were significantly higher than those in remission stage, pneumonia group and normal control group(P＜0.05).There was no significant difference on serum levels of Cys LTs,MCP-4,MDC between pneumonia group and asthma remission group(P>0.05),which were significantly higher than those in normal control group(P< 0.05).The levels of Cys LTs,MCP-4 and MDC in peripheral blood of children with different severity categories of asthma were significantly higher than those of normal control group(P<0.05).Pearson analysis indicated that there were positive correlations between the levels of Cys LTs and MCP-4,MDC and MCP-4,Cys LTs and MDC(r=0.865,0.812,0.893,P＜0.01). Conclusions Cys LTs,MCP-4 and MDC are involved in many aspects of asthma. Cys LTs,MCP-4 and MDC in peripheral blood have important clinical value in the assessment of asthma in children.

Key words: asthma, cysteamine leukotriene, monocyte chemoattractant protein-4, macrophage-derived chemokine