关键词: 辅助生殖技术, 体格发育, 精神发育, 儿童

Abstract: Objective To study the long-term status of physical and psychomotor development in children born after assisted reproductive technology(ART),in order to evaluate the safety of ART.Methods Totally 210 children aged 6 months to 6 years,who were born after ART in Reproductive Center of Jiangsu People′s Hospital from January 2010 to June 2015,were enrolled as ART group,and 139 children matched with general characteristics were selected as control group.The psychomotor development of participants were assessed with Chinese Wechsler Preschool and Primary Scale of Intelligence(C-WPPSI) (for children under 4 years old) and Gesell Developmental Diagnosis Scale (GESELL) ( for children over 4 years old). Results Totally 349 children participated in this study,of which 225 were assessed with GESELL test and 124 were tested with C-WPPSI.In addition to the parents′ age (father 33.21±4.46 vs.31.16±3.52,t=2.99;mother 31.65±5.21 vs.29.55±4.07,t=3.93),the proportion of twins (20.0% vs.7.3%,χ²=7.24) and the cesarean section rate (80.4% vs.57.6%,χ²=11.31) of ART group were significantly higher than those of normal control group (P＜0.01).However,there were no significant differences on Z scores of height,weight and body mass index (BMI) between ART group and normal control group (P＞0.05).The long-term physical and psychomotor development of the offspring by ART group were not statistically significant compared with that in NC group (P＞0.05). Conclusion The offspring born after ART and normal delivery have no significant differences on physical and psychomotor development when followed up to 6 years old,indicating ART is relatively safe on physical and psychomotor development.

Key words: assisted reproductive technology, physical development, psychomotor development, children