生命早期补充二十二碳六烯酸与婴儿过敏性疾病的关系

doi:10.11852/zgetbjzz2020-1097

中国儿童保健杂志 ›› 2020, Vol. 28 ›› Issue (12): 1322-1327.DOI: 10.11852/zgetbjzz2020-1097

生命早期补充二十二碳六烯酸与婴儿过敏性疾病的关系

王倩¹, 朱穗¹, 胡芳²

1 暨南大学基础医学院预防医学系医学统计教研室,广东广州 510630;
2 广州医科大学附属广州市妇女儿童医疗中心儿童保健部,广东广州 510623

收稿日期:2020-06-10 修回日期:2020-08-12 发布日期:2020-12-10 出版日期:2020-12-10
通讯作者: 胡芳,E-mail:hufang0351083@126.com
作者简介:王倩(1996-),女,硕士研究生,主要研究方向为流行病与卫生统计。
基金资助:
中国疾病预防控制中心妇幼保健中心合生元母婴营养与健康研究(2018FYH008)

Study on the relationship between docosahexaenoic acid and children′s allergic diseases in early life

WANG Qian¹, ZHU Sui¹, HU Fang²

1 Department of Medical Statistics, School of Basic Medicine, Jinan University, Guangzhou, Guangdong 510630, China;
2 Department of Child Healthcare, Guangzhou Women and Children′s Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510623, China

Received:2020-06-10 Revised:2020-08-12 Online:2020-12-10 Published:2020-12-10
Contact: HU Fang, E-mail: hufang0351083@126.com

摘要/Abstract

摘要： 目的研究母亲孕期补充二十二碳六烯酸(DHA)与子代患过敏性疾病的关系,为婴儿过敏性疾病防治提供新思路。方法选取2017年6月-2018年11月在广州市妇女儿童医疗中心分娩并进行儿童保健的806对母子,采用食物频率问卷、儿童过敏性疾病问卷等获取母亲孕期和哺乳期饮食模式、DHA补充情况,及筛选过敏性疾病可疑患儿。对可疑过敏性疾病患儿进行特异性IgE抗体检测进行确诊。结果在806名儿童中,过敏性疾病发病率为26.2%(211/806),其中湿疹的发病率为23.0%(185/806),食物过敏的发病率为8.7%(70/806)。母亲孕期DHA补充剂量≥250 mg/d时,儿童患过敏性疾病(OR=0.10,95%CI:0.01~0.79)、湿疹(OR=0.02,95%CI:0.01~0.20)的风险随着补充剂量的增加而降低。母亲有过敏史,增加其子代过敏性疾病、湿疹、食物过敏的发生风险(OR分别为4.09、23.75、14.71,P<0.05)。结论母亲孕期DHA补充剂量达到一定剂量时,可能是儿童患过敏性疾病的保护因素,而DHA补充与食物过敏的关系需要进一步探讨。

关键词: DHA, 过敏性疾病, 儿童, 湿疹, 食物过敏

Abstract: Objective To discuss the relationship between docosahexaenoic acid (DHA) supplementation during pregnancy and offspring′s allergic diseases,in order to provide new ideas for the prevention and treatment of allergic diseases in infants. Methods From June 2017 to November 2018, totally 806 children who were born and took child health care in Guangzhou Women and Children′s Medical Center were enrolled in this study.Food frequency questionnaires, child allergic diseases questionnaires were used to obtain the diet patterns during pregnancy and lactation, DHA supplementation information, and screening of children with suspected allergic diseases.The diagnosis of specific IgE antibodies was performed in children with suspected allergic diseases. Results Among the 806 children, the incidence of allergic disease was 26.2%(211/806), of which the incidence of eczema and food allergy was 23.0%(185/806) and 8.7%(70/806), respectively.The risk of allergic diseases(OR=0.10,95%CI:0.01-0.79) and eczema(OR=0.02, 95%CI:0.01—0.20) in children decreased with the increasing dose of maternal DHA supplementation when the dose was greater than 250 mg/d during pregnancy(P<0.05).Mothers′ history of allergy increased the risk of allergic diseases, eczema, food allergies in the offspring(OR=4.09, 23.75, 14.71,P<0.05). Conclusion Maternal DHA supplementation at a certain dose during pregnancy may be a protective factor against allergic disease in children, but the relationship between DHA supplementation and food allergy needs to be further explored.

Key words: DHA, allergic disease, children, eczema, food allergy

中图分类号:

R725.9

王倩, 朱穗, 胡芳. 生命早期补充二十二碳六烯酸与婴儿过敏性疾病的关系[J]. 中国儿童保健杂志, 2020, 28(12): 1322-1327.

WANG Qian, ZHU Sui, HU Fang. Study on the relationship between docosahexaenoic acid and children′s allergic diseases in early life[J]. journal1, 2020, 28(12): 1322-1327.

参考文献

[1] Calderon MA, Demoly P, Wijk R Gerthvan, et al.EAACI: Aeuropean declaration on immunotherapy.Designing the future of allergen specific immunotherapy[J].Clin Transl Allergy, 2012,2:20.
[2] Noakes PS, Vlachava M, Kremmyda LS, et al.Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo[J].Am J Clin Nutr, 2012, 95(2): 395-404.
[3] Stoney RM, Woods RK, Hosking CS,et al.Maternal breast milk long-chain n-3 fatty acids are associated with increased risk of atopy in breastfed infants[J].Clin Exp Allergy, 2004, 34(2): 194-200.
[4] 中华医学会妇产科学分会产科学组.孕前和孕期保健指南(2018)[J].中华妇产科杂志, 2018, 53(1): 7-13.
[5] Venter C, Brown KR, Maslin K, et al.Maternal dietary intake in pregnancy and lactation and allergic disease outcomes in offspring[J].Pediatr Allergy Immunol, 2017, 28(2): 135-143.
[6] 陶鋆, 蔡莉.生命早期多不饱和脂肪酸摄入对儿童过敏性疾病的影响研究[J].中华疾病控制杂志, 2017, 21(1): 94-98.
[7] Furuhjelm C, Warstedt K, Larsson J,et al.Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy[J].Acta Pediatrica, 2009, 98(9): 1461-1467.
[8] Furuhjelm C, Warstedt K, Fageras M, et al.Allergic disease in infants up to 2 years of age in relation to plasmaomega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation[J].Pediatr Allergy Immunol, 2011, 22(5): 505-514.
[9] 齐可民, 樊超男.n-3多不饱和脂肪酸与儿童生长发育和健康[J].中华实用儿科临床杂志, 2016, 31(23): 1761-1765.
[10] Birch EE, Khoury JC, Berseth CL, et al.The impact of early nutrition on incidence of allergic manifestations and common respiratory illnesses in children[J].J Pediatr, 2010,156(6): 902-906.
[11] Elsen L, Garssen J, Willemsen L.Long chain n-3 polyunsaturated fatty acids in the prevention of allergic and cardiovascular disease[J].Current Pharmac Design, 2012, 18(16): 2375-2392.
[12] 邓莎莎, 陈铮, 彭咏梅.不同过敏体质母亲母乳中PUFAs与免疫因子的差异及相互性研究[J].中国儿童保健杂志, 2016, 24(4): 344-349.
[13] Campbell DE, Boyle RJ, Thornton CA, et al.Mechanisms of allergic disease-environmental and genetic determinants for the development of allergy[J].Clin Exp Allergy, 2015, 45(5): 844-858.
[14] Kim H,Sitarik AR, Woodcroft K, et al.Birth mode, breastfeeding, pet exposure, and antibiotic use: associations with the gut microbiome and sensitization in children[J].Curr Allergy Asthma Rep, 2019, 19:(22): 1-9.
[15] 胡芳, 卢建军, 胡艳, 等.剖宫产可能增加儿童罹患过敏性疾病风险的Meta分析[J].中国儿童保健杂志, 2018, 26(9): 985-990.
[16] Bager P, Wohlfahrt J, Westergaard T.Caesarean delivery and risk of atopy and allergic disease: meta-analyses[J].Clin Exp Allergy, 2008, 38(4): 634-642.
[17] 屈芳, Weschler LB, Sundell J, 等.纯母乳喂养对北京学龄前儿童哮喘和过敏性疾病患病率的影响[J].科学通报, 2013, 58(25): 2513-2526.
[18] Andreas NJ, Kampmann B, Le-Doare KM.Human breast milk: A review on its composition and bioactivity[J].Early Human Develop, 2015, 91(11): 629-635.

生命早期补充二十二碳六烯酸与婴儿过敏性疾病的关系

Study on the relationship between docosahexaenoic acid and children′s allergic diseases in early life

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