关键词: 促肾上腺皮质激素, 皮质醇, 1型糖尿病, 糖化血红蛋白

Abstract: Objective To Analyze the correlation between adrenocorticotropic hormone(ACTH),cortisol(CORT) and glycated hemoglobin(HbA1c) levels in children with type 1 diabetes mellitus(T1DM),so as to provide scientific evidence for the clinical diagnosis of T1DM. Methods A total of 105 T1DM children hospitalized in the Department of Endocrinology of Tangshan Maternal and Child Health Hospital from January 2014 to December 2018 were selected as the T1DM group,and meanwhile 105 healthy children were selected as the control group. The levels of plasma ACTH and CORT at different time points (8:00,16:00 and 24:00) were measured by enzyme-linked immunosorbent assay (ELISA). Pearson method was used to analyze the correlation between the daily average levels of ACTH,CORT and fasting blood glucose (FPG),HbA1c and other indicators. In addition,Logistic regression analysis was used to analyze the risk factors of T1DM. Results Compared with those in the control group,the levels of triglyceride (TG),total cholesterol (TC),low density lipoprotein (LDL-C),FPG and HbA1c were significantly increased in T1DM group(P＜0.05),while the level of high-density lipoprotein (HDL-C) was decreased (P＜0.05). The expression level of ACTH and CORT at 8:00,16:00 and 24:00,and the daily average levels in plasma of T1DM group were significantly higher than those in control group (P＜0.05). Correlation analysis showed that the daily average expression levels of ACTH and CORT were positively correlated with FPG and HbA1c (r_ACTH=0.717,0.585, r_CORT=0.636,0.696,P<0.01). Logistic regression analysis showed that ACTH and CORT were independent risk factors of T1DM. Conclusions ACTH and CORT are highly expressed in plasma of T1DM children,which are correlated with HbA1c. As independent risk factors for the onset of T1DM,ACTH and CORT may be used as potential markers for glycemic control of T1DM.

Key words: adrenocorticotropic hormone, cortisol, type 1 diabetes mellitus, glycosylated hemoglobin