关键词: 孤独症, 生命早期, 儿童

Abstract: Objective To explore the risk factors of childhood autism in early life,in order to provide reference for early prevention of autism. Methods A total of 100 children newly diagnosed with autism in a tertiary hospital in Hefei from June to September,2019,were enrolled in the case group.And 198 typical developed children were selected as the control group,matched by gender and age in 1∶2 case control study.Basic information of the family,mother′s situation during pregnancy and delivery period,and the children′s situation within 2 years after birth were investigated. Results Logistic regression analysis showed that marriage between blood relatives within three generations(OR=13.154,95%CI:2.225-77.785),epilepsy,mental retardation,dyskinesia or mental illness within three generations(OR=8.245,95%CI:2.165-31.394),maternal introversion personality(OR=3.263,95%CI:1.345-7.919),taking broad-spectrum antibiotics during pregnancy(OR=4.967,95%CI:1.344-18.362),premature(OR=3.698,95%CI:1.543-8.858)were risk factors for autism.Neonatal performance(compared with abnormal quiet,crying OR=0.275,95% CI:0.097-0.782),outdoor activity for at least 1 hour/day within 2 years old(1-2 hours/day OR=0.203,95%CI:0.050-0.828,＞2 hours/day OR=0.189,95%CI:0.048-0.747)were the protective factors of autism. Conclusions The occurrence of autism is affected by genetic factors,mother′s personality type,antibiotic use during pregnancy,premature delivery,neonatal performance and outdoor activity time within 2 years old.It is suggested to strengthen the early prevention and treatment of autism from the perspectives of these aspects.

Key words: autism, early life, children