关键词: 早产儿, 喂养不耐受, 肠内喂养

Abstract: Objective To analyze the clinical manifestations and related factors of feeding intolerance in premature infants (<34 weeks gestation), in order to provide reference for the prevention and treatment feeding intolerance. Methods A total of 107 premature infants <34 weeks gestation in Tonglu Maternity and Child Health Care Hospital from February 2018 to August 2020 were selected in this study. The basic data, clinical manifestations and feeding tolerance of maternal and premature infants were investigated by self-made questionnaire and medical records. The related influencing factors of feeding intolerance of premature infants <34 weeks gestation were analyzed by univariate and multivariate Logistic regression analysis. Results In this study, 36.45% of very preterm infants had feeding intolerance. Univariate analysis showed that lower birth weight, abnormal umbilical cord, multiple births, late start of feeding, late enteral feeding up to 110kCal/kg, late enteral feeding up to 150kCal/kg and late evacuation of faeces were the risk factors of feeding intolerance in premature infants (P<0.05). Multivariate Logistic regression analysis showed that higher birth weight was an independent protective factor for feeding intolerance in premature infants (OR=0.003, 95%CI:0.000 - 0.789, P<0.05), while late start of feeding(OR=1.213, 95%CI:1.011 - 1.456), late enteral feeding up to 110kCal/kg(OR=1.525, 95%CI:1.186 - 1.960), late enteral feeding up to 150kCal/kg(OR=1.230, 95%CI:1.097 - 1.378) and late evacuation of faeces (OR=1.505, 95%CI:1.027 - 2.207) were independent risk factors for feeding intolerance in premature infants (P<0.05). Conclusion It is necessary to pay close attention to the premature infants with lower birth weight, late start of feeding, late enteral feeding up to 110kCal/kg, late enteral feeding up to 150kCal/kg and late defecation, and take timely and effective interventions for the above factors.

Key words: premature infants, feeding intolerance, late enteral feeding