关键词: 出生缺陷, 病例对照, Logistic回归分析

Abstract: Objective To investigate the risk factors of birth defects in center of Wuhan city, and to provide scientific evidence for the interventions. Methods A 1∶4 matched case-control study was conducted, 386 mothers of birth defects children and 1 544 controls were investigated retrospectively.Data were analyzed for descriptive study, univariate Logistic regression and 1∶4 matched conditional Logistic regression with SAS9.2 statistical software. Results The following factors were found to be significantly related to birth defectsmaternal exposure to teratogenic factors during pregnancy (OR=1.602), passive smoking (OR=1.002), good state of health during pregnancy (OR=0.943), adhere to exercise during pregnancy (OR=0.952), cesarean section(OR=0.853) and once the number of live births childbirth (OR=0.712). Conclusion Maternal exposure to teratogenic factors during pregnancy and passive smoking are risk factor for birth defects, good state of health during pregnancy, adhere to exercise during pregnancy, cesarean section and the number of live births are protective factors for birth defects.

Key words: birth defects, case-control, Logistic regression