关键词: 早期持续小剂量补充铁剂, 粗大运动, 言语认知发育, 睡眠规律, 体格发育, 追赶生长

Abstract: Objective To study the effect of continuous low-dose iron supplementation for preterm infants,and to provide evidence for recommendation way of iron supplementation. Methods A prospective longitudinal cohort method was used to collect 530 cases of high-risk premature infants from 2010 to 2016,234 cases of full-term infants were divided into three groups by different doses and iron treatment times.The intelligence development and physical development were evaluated by Gesell Developmental Schedules (GDS).The development of each group was observed to 12 months old. Results In 12 months old,there were significant differences on the development quotient (DQ) of gross motor (GM),persona-social behavior(PS),cognitive development (CG),communication (CM) and sleep regularity between group A and group B (P<0.05);And the above items between the observation group (group A) and normal control group (group C) showed no significant difference (P>0.05).And the differences on physical development among three groups were statistically significant (P<0.05). Conclusion Continuous low-dose iron supplementation has greater effect on the sleep and neuromotor speech cognitive development,but has little effect on physical development.

Key words: early continuous low-dose iron supplementation, gross motor development, speech cognitive development, sleep patterns, physical development, catch-up growth