食物过敏对孤独症谱系障碍的影响及机制研究

doi:10.11852/zgetbjzz2018-26-04-11

摘要/Abstract

摘要： 孤独症谱系障碍(ASD)在近年来发病率不断上升,引起人们的广泛关注。目前已有研究表明,过敏性疾病与孤独症谱系障碍之间关系密切,而食物过敏作为一种常见的过敏性疾病,与孤独症谱系障碍也存在联系。本文通过查阅相关文献,就食物过敏对孤独症谱系障碍的影响及相关机制研究进展进行综述,为探索孤独症谱系障碍的病因及治疗方法提供帮助。

关键词: 食物过敏, 孤独症谱系障碍, 机制

Abstract: Autism spectrum disorder (ASD) and allergic diseases have been increasing in recent years.Currently,existed research have shown that there was a close relation in mechanism between autism spectrum disorders and allergic diseases,including food allergy.This article reviews recent progress on the effects and mechanisms of food allergy on autism spectrum disorders.

Key words: food allergy, autism spectrum disorder, mechanism

中图分类号:

R179

卢明悦综述, 胡燕审校. 食物过敏对孤独症谱系障碍的影响及机制研究[J]. 中国儿童保健杂志, 2018, 26(4): 389-391.

LU Ming-yue, HU Yan. Review on the effects and mechanisms of food allergy on autism spectrum disorders[J]. journal1, 2018, 26(4): 389-391.

参考文献

[1] Ronald VR,Lars KP,Gary WKW,等.食物过敏的定义、流行性、诊断及治疗[J].中华预防医学杂志,2015,49(1):87-92.
[2] Prescott S.Food allergy:riding the second wave of the allergy epidemic[J].PAI,2011,22(2):155-160.
[3] Faroy M,Meiri G.DSM-5 and autism:diagnostic changes and clinical implications in early childhood[J].Harefuah,2016,155(5):291-295,322.
[4] Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators;Centers for Disease Control and Prevention(CDC).Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network,11 sites,United States,2010[J].MMWR Surveill Summ,2014,63(2):1-21.
[5] Goldson E.Advances in autism-2016[J].Adv Pediatr,2016,63 (1):333-355.
[6] Wu J,de Theije CG,da Silva SL,et al.mTOR plays an important role in cow's milk allergy-associated behavioral and immunological deficits[J].Neuropharmacology,2015,97:220-232.
[7] Aldinger KA,Lane CJ,Veenstra-VanderWeele J.Patterns of risk for multiple co-occurring medical conditions replicate across distinct cohorts of children with autism spectrum disorder[J].INSAR,2015,8(6):771-781.
[8] Adams JB,Johansen LJ,Powell LD,et al.Gastrointestinal flora and gastrointestinal status in children with autism--comparisons to typical children and correlation with autism severity[J].BMC Gastroenterol,2011,11:22.
[9] Gurney JG,Mc Pheeters ML.Parental report of health conditions and health care use among children with and without autism:National survey of children's health[J].Arch Pediat Adol Med,2006,160(8):825-830.
[10] De Theije CG,Wu J,Koelink PJ,et al.Autistic-like behavioural and neurochemical changes in a mouse model of food allergy[J].Behav Brain Res,2014,261(6):265-274.
[11] Lyall K,Van de Water J,Ashwood P.Asthma and allergies in children with autism spectrum disorders:results from the charge study[J].Autism Res,2015,8:567-574.
[12] de Theije CG,Bavelaar BM,Lopes da Silva S,et al.Food allergy and food-based therapies in neurodevelopmental disorders[J].Pediatr Allergy Immu,2014,25(3):218-226.
[13] Kennedy PJ,Clarke G,Quigley EM,et al.Gut memories:towards a cognitive neurobiology of irritable bowel syndrome[J].Neurosci Biobehav R,2012,36(1):310-340.
[14] Ashwood P,Enstrom A,Krakowiak P,et al.Decreased transforming growth factor beta1 in autism:a potential link between immune dysregulation and impairment in clinical behavioral outcomes[J].J Neuroimmunol,2008,204(1-2):149-153.
[15] Jyonouchi H,Geng L,Ruby A,et al.Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders[J].J Pediatr,2005,146(5):605-610. [16] 阳青兰.消化道微生物组与孤独症研究进展[J].国际检验医学杂志,2017,38(6):741-743.
[17] Khakzad MR,Salari F,Javanbakht M,et al.Transforming growth factor beta 1 869T/C and 915G/C polymorphisms and risk of autism spectrum disorders[J].J Biochem Mol Biol,2015,3(2):82-88.
[18] Akin C,Valent P.Urticaria pigmentosa and mastocytosis:the role of immunophenotyping in diagnosis and determining response to treatment[J].Curr Allergy Asthma Rep,2006,6(4):282-288.
[19] Theoharides TC.Autism spectrum disorders and mastocytosis[J].Int J Immunopathol Pharmacol,2009,22(4):859-865.
[20] Ronchetti R,Jesenak M,Barberi S,et al.Reproducibility of atopy patch tests with food and inhalant allergens[J].J Biol Reg Homeos Ag,2008,22(1):27-33.
[21] Tillisch K,Labus J,Kilpatrick L,et al.Consumption of fermented milk product with probiotic modulates brain activity[J].Gastroenterology,2013,144(7):1394-1401.
[22] Tazoe H,Otomo Y,Kaji I,et al.Roles of short-chain fatty acids receptors,GPR41 and GPR43 on colonic functions[J].J Physiol Pharmacol,2008,59(Suppl 2):251-262.
[23] Finegold SM,Dowd SE,Gontcharova V,et al.Pyrosequencing study of fecal microflora of autistic and control children[J].Anaerobe,2010,16(4):444-453.
[24] Tomova A,Husarova V,Lakatosova S,et al.Gastrointestinal microbiota in children with autism in Slovakia[J].Physiol Behav,2015,138:179-187.
[25] Prince BT,Mandel MJ,Nadeau K.Gut Microbiome and the Development of Food Allergy and Allergic Disease[J].Pediatr Clin North Am,2015,62(6):1479-1492.
[26] Berni Canani R,Sangwan N,Stefka AT,et al.Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants[J].ISME J,2016,10(3):742-750.
[27] Williams BL,Hornig M,Buie T,et al.Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances[J].PLoS One,2011,6(9):e24585.
[28] Atarashi K,Tanoue T,Oshima K,et al.Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota[J].Nature,2013,500(7461):232-236.
[29] Tan J,McKenzie C,Vuillermin PJ,et al.Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways[J].Cell Reports,2016,15(12):2809-2824.
[30] de Magistris L,Familiari V,Pascotto A,et al.Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives[J].JPGN,2010,51(4):418-424.
[31] Whiteley P,Haracopos D,Knivsberg AM,et al.The ScanBrit randomised,controlled,single-blind study of a gluten- and casein-free dietary intervention for children with autism spectrum disorders[J].Nutr Neurosci,2010,13(2):87-100.