特发性中枢性性早熟女童血清瘦素、网膜素-1和脂联素表达水平及意义

doi:10.11852/zgetbjzz2020-1299

中国儿童保健杂志 ›› 2021, Vol. 29 ›› Issue (7): 783-786.DOI: 10.11852/zgetbjzz2020-1299

特发性中枢性性早熟女童血清瘦素、网膜素-1和脂联素表达水平及意义

颜松, 刘芳

重庆市大足区人民医院儿科,重庆 402360

收稿日期:2020-07-08 修回日期:2020-09-03 发布日期:2021-07-28 出版日期:2021-07-10
通讯作者: 刘芳,E-mail:yikedaxue001@yeah.net
作者简介:颜松(1990-),男,重庆人,医师,本科学历,研究方向为儿科相关疾病诊断与治疗。

Expression and significance of serum leptin,omentum-1 and adiponectin in girls with idiopathic central precocious puberty

YAN Song, LIU Fang

Department of Pediatrics,The People's Hospital of Dazu, Chongqing 402360,China

Received:2020-07-08 Revised:2020-09-03 Online:2021-07-10 Published:2021-07-28
Contact: LIU Fang,E-mail:yikedaxue001@yeah.net

摘要/Abstract

摘要： 目的分析血清瘦素、网膜素-1和脂联素在女童特发性中枢性性早熟(ICPP)的诊断价值,为临床应用提供理论依据。方法选取2017年4月—2019年8月重庆市大足区人民医院124例ICPP女童、86例单纯性乳房发育(PT)女童和100例健康女童为研究对象。用酶联免疫吸附实验检测血清瘦素、网膜素-1 和脂联素水平。受试者工作特征曲线 (ROC)曲线分析各指标在诊断及鉴别诊断中的价值,计算曲线下面积(AUC)。结果与对照组比较,ICPP组瘦素水平较高,网膜素-1和脂联素水平较低(P＜0.05),PT组瘦素水平较高,网膜素-1水平较低(P＜0.05);与PT组比较,ICPP组瘦素水平较高,网膜素-1水平较低(P＜0.05)。瘦素、网膜素-1 和脂联素诊断ICPP的AUC分别为0.898、0.842和0.799,三者联合检测可将AUC提高至0.920;瘦素、网膜素-1 和脂联素鉴别诊断ICPP和PT的AUC分别为0.761、0.604和0.572,三者联合检测可将AUC提高至0.775。结论血清脂肪因子瘦素、脂联素和网膜素-1在ICPP的诊断及与PT的鉴别诊断中有一定临床价值。

关键词: 瘦素, 网膜素-1, 脂联素, 乳房早发育, 特发性中枢性性早熟

Abstract: Objective To investigate the diagnostic value of serum leptin,omentin-1 and adiponectin in girls with idiopathic central precocious puberty (ICPP),in order to provide evidence for the clinical application. Methods From April 2017 to August 2019,124 girls with ICPP,86 girls with premature thelarche (PT) and 100 healthy girls were selected as the study objects. The levels of serum leptin,omentin-1 and adiponectin were tested by enzyme-linked immunosorbent assay. ROC curve was used to analyze the value of each index in diagnosis and differential diagnosis,and AUC was calculated. Results Compared with the control group,the level of leptin was higher,omentin-1 and adiponectin were lower in ICPP group (P<0.05). Leptin level was higher and omentin-1 level was lower in PT group than that in control group (P<0.05). Compared with PT group,the level of leptin was higher and omentin-1 was lower in ICPP group (P<0.05). The AUC of leptin,omentin-1 and adiponectin in the diagnosis of ICPP was 0.898,0.842 and 0.799,respectively. The combined detection of the three indicators increased AUC to 0.920. The AUC of leptin,omentin-1 and adiponectin in the differential diagnosis of ICPP and PT were 0.761,0.604 and 0.572,respectively. The combined detection of the three indicators increased AUC to 0.775. Conclusion Serum adipokine leptin,adiponectin and omentum-1 have certain clinical value in the diagnosis of ICPP and the differential diagnosis between ICPP and PT.

Key words: leptin, omentin-1, adiponectin, premature thelarche, idiopathic central precocious puberty

中图分类号:

R725.8

颜松, 刘芳. 特发性中枢性性早熟女童血清瘦素、网膜素-1和脂联素表达水平及意义[J]. 中国儿童保健杂志, 2021, 29(7): 783-786.

YAN Song, LIU Fang. Expression and significance of serum leptin,omentum-1 and adiponectin in girls with idiopathic central precocious puberty[J]. Chinese Journal of Child Health Care, 2021, 29(7): 783-786.

参考文献

[1] Ge W,Wang HL,Shao HJ,et al. Evaluation of serum makorin ring finger protein 3 (MKRN3) levels in girls with idiopathic central precocious puberty and premature thelarche[J]. Physiol Res,2020,69(1):127-133.
[2] 田佳梅,王锁英.肠道菌群与肥胖及性早熟关系的研究进展[J]. 中国学校卫生,2019,40(9):1437-1440.
[3] 赵悦.女童肥胖与特发性中枢性性早熟的相关性的多因素分析[D]. 武汉:华中科技大学,2017.
[4] Chen C,Zhang Y,Sun W,et al. Investigating the relationship between precocious puberty and obesity:a cross-sectional study in Shanghai,China[J].BMJ Open,2017,7(4):e014004.
[5] 史娇娇,马壮,任华,等.肥胖和运动对下丘脑Leptin-Kisspeptin-GnRH通路的影响[J]. 中国优生与遗传杂志,2016,24(4):1-2,27.
[6] Landecho MF,Tuero C,Valentí V,et al. Relevance of leptin and other adipokines in obesity-associated cardiovascular risk[J]. Nutrients,2019,11(11):2664-2670.
[7] 中华医学会儿科学分会内分泌遗传代谢学组,《中华儿科杂志》编辑委员会.中枢性性早熟诊断与治疗共识(2015)[J]. 中华儿科杂志,2015,53(6):412-418.
[8] 吴慧平,金献江,罗越,等.血清基质金属蛋白酶2与骨代谢标志物水平对女童特发性中枢性性早熟的诊断价值研究[J]. 中国全科医学,2015,18(11):1264-1269.
[9] 袁博,皮亚雷,张亚男,等. GnRHa激发试验与GnRH激发试验诊断价值的对比研究[J]. 国际儿科学杂志,2019,46(6):453-456.
[10] 戴丽凤,田华,杨群燕,等.儿童性早熟流行病学特征及相关影响因素分析[J]. 中国公共卫生管理,2017,33(1):136-137,142.
[11] Kaya A,Orbak Z,Polat Ï,et al. Leptin and neuropeptide Y levels in newborns[J]. J Pediatr Endocrinol Metab,2016,29(1):21-25.
[12] 袁临益.特发性中枢性性早熟女孩瘦素和脂联素与胰岛素抵抗的关系[J]. 中国实用儿科杂志,2007,22(12):942-943.
[13] 宋艳丽,孙自学,卫爱武.二甲双胍对多囊卵巢综合征大鼠血清中网膜素-1水平的影响[J]. 东南大学学报(医学版),2019,38(1):23-27.
[14] 白涛,杨静,王艳玲,等. 性激素对脂肪细胞瘦素和脂联素分泌的影响[J]. 中华内分泌代谢杂志,2011,27(12):1009-1012.
[15] Österbrand M,Fors H,Norjavaara E. Prevalence of premature thelarche at 18 months of age:a population- and hospital-based study of prevalence and incidence in girls born at northern älvsborg county hospital in Sweden[J]. Horm Res Paediatr,2019,91(3):203-209.
[16] 朱廷富,邵华江. 特发性中枢性性早熟与单纯性乳房早发育的鉴别诊断[J]. 中国性科学,2015,18(9):49-52.

特发性中枢性性早熟女童血清瘦素、网膜素-1和脂联素表达水平及意义

Expression and significance of serum leptin,omentum-1 and adiponectin in girls with idiopathic central precocious puberty

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	宾雅棣, 付佳蕾, 兰楠, 贾艺玮, 陈丽, 雷晓梅. 瘦素对慢性束缚应激导致青春期抑郁和学习记忆障碍的改善及机制研究[J]. 中国儿童保健杂志, 2023, 31(6): 629-633.
[2]	崔一帆, 董明明, 胡丹, 马贤芝, 肖绪武. 血清趋化素、瘦素、脂联素浓度与学龄前单纯性肥胖儿童糖脂代谢的关系[J]. 中国儿童保健杂志, 2022, 30(5): 548-552.
[3]	杨眉, 李海艳, 侯会丹, 韩敬, 陶月红. 食欲素-A在下丘脑-垂体-性腺轴启动中的作用[J]. 中国儿童保健杂志, 2021, 29(7): 730-733.
[4]	段鹏, 陈丽, 胡浩, 苟玮, 刘利, 雷晓梅. 瘦素改善慢性应激导致青春期小鼠焦虑样行为的研究[J]. 中国儿童保健杂志, 2020, 28(9): 989-992.
[5]	张建, 周红娟, 高锦萍, 赵琴. 中枢性性早熟女童体重指数与性激素及瘦素、脂联素水平的相关性研究[J]. 中国儿童保健杂志, 2020, 28(2): 187-190.
[6]	周兰梅, 王琼瑾, 季翠芳. 双酚A暴露水平与学龄期女童特发性性早熟风险之间的关系[J]. 中国儿童保健杂志, 2020, 28(11): 1250-1254.
[7]	黄晓燕, 陈积雄, 罗海伶, 向伟. 单纯乳房早发育和中枢性性早熟女童血清25羟维生素D水平的分析[J]. 中国儿童保健杂志, 2019, 27(8): 831-834.
[8]	许慧洁,叶进,袁雪晶,曹建梅,李辉,张俞. 促性腺激素释放激素类似物改善特发性中枢性性早熟女童成年身高及相关因素分析[J]. 中国儿童保健杂志, 2019, 27(3): 262-264.
[9]	刘利, 苟伟, 谢雯, 陈丽, 雷晓梅. 不同强度运动训练对青春期大鼠学习记忆能力的影响及其机制研究[J]. 中国儿童保健杂志, 2019, 27(1): 42-45.
[10]	张美真,刘悦笙,王敏,尹春燕,王莉,肖延风. 血清网膜素-1水平与儿童非酒精性脂肪肝的关系[J]. 中国儿童保健杂志, 2018, 26(9): 940-943.
[11]	王琰华, 赵忻, 刘冀琴. 天津市女童单纯乳房早发育及特发性中枢性性早熟发病危险因素的分析[J]. 中国儿童保健杂志, 2018, 26(4): 444-447.
[12]	王琰华, 赵忻. GnGHa治疗对特发性中枢性性早熟女童血清P1NP、β-CTX、N-MID水平的影响及其临床意义[J]. 中国儿童保健杂志, 2017, 25(12): 1288-1289.
[13]	庞隐, 张汝娟, 杜晓娅. 血清脂联素对极低出生体重早产儿胃肠外营养相关性胆汁淤积的相关性分析[J]. 中国儿童保健杂志, 2016, 24(9): 951-953.
[14]	张瑞杰,史云菊,程美英,张德甫. 磁共振鉴别女童特发性性早熟与单纯乳房早发育的探讨[J]. 中国儿童保健杂志, 2015, 23(7): 736-738.
[15]	金辉, 马路一. 矢车菊素-3-葡萄糖苷对肥胖大鼠低度炎症反应及胰岛素敏感性的影响[J]. 中国儿童保健杂志, 2014, 22(8): 826-828.