关键词: 哮喘, 25-羟维生素D₃, 总免疫球蛋白E, 肺功能

Abstract: Objective To observe the changes of 25 hydroxy vitamin D₃[25-(OH)D₃] concentration in the serum of children with asthma, and to analyse its relationship with the content of serum total immunoglobulin E(TIgE )and lung function index associated with asthma. Methods Serum 25-(OH )D₃, TIgE content and lung function index were tested in experimental group consisting of 42 patients suffered from asthma, and in control group consisting of 48 children with no asthma.Then comparisons were analyzed between the two groups. Results Compared with the normal control group, serum 25-(OH)D₃ level content in experimental group consisting of children with asthma was significantly decreased (P<0.01), but the serum TIgE content increased significantly (P<0.01);serum 25-(OH)D₃ level in experimental group composed of children with asthma was negatively correlated with TIgE (P<0.01), and positively correlated with forced expiratory small airway 25% flow (MEF25)and forced expiratory volume 50%(MEF50)(P<0.05). Conclusion Vitamin D deficiency is an important cause of asthma exacerbations in children, which may be related to inhibitory effect of 25-(OH)D₃ on the TIgE.

Key words: children asthma, 25-hydroxy vitamin D₃, total immunoglobulin E, pulmonary function