孤独症发生和发展的生化机制及实践应用启示

中国儿童保健杂志 ›› 2012, Vol. 20 ›› Issue (10): 907-910.

孤独症发生和发展的生化机制及实践应用启示

郭德华,杨广学

华东师范大学学前与特殊教育学系,上海 200062

收稿日期:2012-03-14 发布日期:2012-10-06 出版日期:2012-10-06
通讯作者: 杨广学, E-mail:yanggx2789@163.com
作者简介:郭德华(1968- ),男,江西人,副教授,博士研究生,研究方向为孤独症康复与干预
基金资助:
上海市哲学社会科学规划课题资助(2008BJY009)

Received:2012-03-14 Online:2012-10-06 Published:2012-10-06

摘要/Abstract

摘要： 孤独症属于神经发育性障碍,其特点是社会交流和语言障碍、刻板重复的行为和兴趣,目前的诊断缺乏客观的生物学指标,主要依靠行为症状学标准和主观判断,研究显示孤独症可能存在身体多系统生物学问题,包括代谢、免疫、肠胃道和神经系统的问题,应用主观的测试(心理或行为量表)无法判断孤独症患者这些激素、代谢和其它生物学标志物相互之间的复杂关系,本文以生化视角梳理和链接当前研究成果和孤独症的生物学客观评估指标,旨在探讨对孤独症病因、诊断、治疗和预防有意义的可能生物标志物。

关键词: 孤独症, 孤独症谱系障碍, 生化机制, 生化指标, 康复干预

中图分类号:

R749.94

郭德华,杨广学. 孤独症发生和发展的生化机制及实践应用启示[J]. 中国儿童保健杂志, 2012, 20(10): 907-910.

参考文献

[1] Martha RH.Autsm:a brain disorder,or a disorder that affects the brain?[J].Clinical Neuropsychiatry,2005,2(6):354-379.
[2] James JB,Scott S,Matthew B,et al.Biomarker-guided interventions of clinically relevant conditions associated with autism sprctrum disorders and attention deficit hyperactivity disorder[J].Alternative Medicine Review.2011,15(1):15-32.
[3] Carr EG,Owen-DeSchryver JS.Physical illness,pain,and problem behavior in minimally verbal people with developmental disabilities[J].Journal of Autism and Developmental Disorders,2007,37(3):413 -424.
[4] Geier DA,Geier MR.A rospective assessment of porphyrins in autistic disorders:a potential marker for heavy metal exposure[J].Neurotoxicity Research,2006,10:57-64.
[5] Croonenberghs J,Wauters A,Deboune D,et al.Central serotonergic hypofunction in autism:results of the 5-hydroxy-tryptophan challenge test[J].Neuroendocrinology Letters,2007,28:449-455.
[6] Polleux F,Lauder JM.Toward a developmental neurobiology of autsm[J].Mental Retardation and Developmental Disabilities Research Reviews,2004,10:303-317.
[7] Belmonte MK,Cook EH,Jr Anderson,et al.Autism as a disorder of neural information processing:directions for research and targets for therapy[J].Molecular Psychiatry,2004,9:646-663.
[8] Geier DA,Kern JK,Garver CR,et al.Biomarkers of environmental toxicity and susceptibility in autism[J].Journal of the Neurological Sciences,2009,280:101-108.
[9] James SJ,Cutler P,Melnyk S,et al.Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism[J].American Journal of Clinical Nutrition,2004,80:1611-1617.
[10] Blaylock PL,Strunecka A.Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders[J].Current Medicinal Chemistry,2009,16:157-170.
[11] Geier DA,Sykes LK,Geier MR.A review of Thimerosal (Merthiolate) and its ethylmercury breakdown product:specific historical considerations regarding safety and effectiveness[J].Journal of Toxicology and Environmental Health Part B:Critical Reviews,2007,10:575-596.
[12] Ivan KS,Yap MA.Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls[J].Journal of Proteome Research,2010,9:2996-3004.
[13] Cecilia G,Zhang YF,Alicja OK,et al.Mitochondrial dysfunction in autism[J].Journal of American Medical Association,2010,304(21):2389-2396.
[14] Knickmeyer RC,wheelwright S,Baron-Cohen SB.Sex-typical play:masculinization/defeminization in girls with an autism spectrum condition[J].Journal of Autism and Developmental Disorders,2008,38:1028-1035.
[15] Evans C,Dunstan RH,Rothkirch T,et al.Altered amino acid excretion in children with autism[J].Nutritional Neuroscience,2008,11:9-17.
[16] Filipek PA,Juranek J,Nguyen MT,et al.Relative carnitine deficinency in autism[J].Journal of Autism Development Disorder,2004,34:615-623.
[17] Hara H.Autism and epilepsy:a retrospective follow-up study[J].Brain Development,2007,29(8):486-490.
[18] Balmiki R,Justin ML,Deborah KS.Increased secreted amyloid precursor protein-a (sAPPa) in severe autism:proposal of a specific,anabolic pathway and putative biomarker[J].Plos One,2011,6(6):e20405:1-10.
[19] Chauhan A,Chauhan V.Oxidative stress in autism[J].Pathophysiology,2006,13:171-181.
[20] Timothy B,Daniel BC.Evaluation,diagnosis,and treatment of gastrointestinal disorders in individuals with ASDs:A consensus report[J].Pediatrics,2010,125(S):1- 18.
[21] Hashimoto K,Lwata Y,Nakamura K,et al.Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism[J].Progress in Neuro-Psychopharmacology & Biological Psychiatry,2006,30:1529-1531.
[22] Galli-Carminati G,Deriaz N,Bertschy G.Melationin in treatment of chronic sleep disorders in adults with autism:a retrospective study[J].Swiss Medical Weekly,2009,139:293-296.
[23] Massimo C,Irene M,Rosanna I,et al.Hypo-phosphorylation of salivary peptidome as a clue to the molecular pathogenesis of autism spectrum disorders[J].Journal of Proteome Research,2008,7:5327-5332.