journal1 ›› 2014, Vol. 22 ›› Issue (7): 733-734.DOI: 10.11852/zgetbjzz2014-22-07-21

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Clinical analysis on the levels of IL-6 and TNF-α in blood plasma of neonates with intracranial haemorrhage.

LIU Yan-hong1, ZHAO Xian-feng2, JIA Mei-yun1, YAN An-ping1   

  1. 1 Department of Neonatology, Zhengzhou People's Hospital, Zhengzhou, Henan 450000, China;
    2 Department of Internal Medicine, Henan Provincial Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan 450000, China
  • Received:2013-12-02 Online:2014-07-10 Published:2014-07-10
  • Contact: YAN An-ping,


刘艳红1, 赵先锋2, 贾美云1, 闫安平1   

  1. 1 郑州人民医院新生儿科, 河南 郑州 450000;
    2 河南省人民医院心血管病医院二病区, 河南 郑州 450000
  • 通讯作者: 闫安平,
  • 作者简介:刘艳红(1972-), 女, 副主任医师, 硕士学位, 主要研究方向为新生儿。

Abstract: Objective To explore the changes and clinical significance of serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in newborns with intracranial hemorrhage. Method The levels of IL-6 and TNF-α blood plasma in 50 neonates with intracranial haemorrhage (case group) and 26 healthy neonates (control group) were detected by ELISA. Results The levels of IL-6 and TNF-α in case group were significantly higher than those in control group (P<0.05);There were significant differences in levels of IL-6 and TNF-α between different amounts of bleeding group (P<0.05). Conclusions Serum levels of IL-6 and TNF-α creases obviously in newborns with intracranial hemorrhage, suggesting that they might be used as reference index in assessing pathogenetic condition and appraising prognosis.

Key words: intracranial haemorrhage, interleukin-6, tumor necrosis factor-α, neonates

摘要: 目的 研究颅内出血足月新生儿血清中白介素-6(IL-6)、及肿瘤坏死因子-α(TNF-α)的变化及其临床意义。方法 用ELISA法测定50例颅内出血足月新生儿和26例健康新生儿的血清 IL-6、TNF-α水平的变化。结果 颅内出血足月新生儿血清IL-6、TNF-α水平明显升高, 与对照组比较, 差异有统计学意义(P<0.05);IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较, 差异有统计学意义(P<0.05);IL-6、TNF-α水平在不同出血量组部位之间IL-6、TNF-α比较, 差异无统计学意义(P>0.05)。结论 颅内出血足月新生儿血清IL-6、TNF-α水平明显增高, 可作为判断病情和评估预后的指标。

关键词: 颅内出血, 白介素-6, 肿瘤坏死因子-α, 新生儿

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