Abstract: Objective To explore the changes and clinical significance of serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in newborns with intracranial hemorrhage. Method The levels of IL-6 and TNF-α blood plasma in 50 neonates with intracranial haemorrhage (case group) and 26 healthy neonates (control group) were detected by ELISA. Results The levels of IL-6 and TNF-α in case group were significantly higher than those in control group (P<0.05);There were significant differences in levels of IL-6 and TNF-α between different amounts of bleeding group (P<0.05). Conclusions Serum levels of IL-6 and TNF-α creases obviously in newborns with intracranial hemorrhage, suggesting that they might be used as reference index in assessing pathogenetic condition and appraising prognosis.

Key words: intracranial haemorrhage, interleukin-6, tumor necrosis factor-α, neonates

摘要： 目的 研究颅内出血足月新生儿血清中白介素-6(IL-6)、及肿瘤坏死因子-α(TNF-α)的变化及其临床意义。方法 用ELISA法测定50例颅内出血足月新生儿和26例健康新生儿的血清 IL-6、TNF-α水平的变化。结果 颅内出血足月新生儿血清IL-6、TNF-α水平明显升高, 与对照组比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组之间IL-6、TNF-α比较, 差异有统计学意义(P＜0.05);IL-6、TNF-α水平在不同出血量组部位之间IL-6、TNF-α比较, 差异无统计学意义(P＞0.05)。结论 颅内出血足月新生儿血清IL-6、TNF-α水平明显增高, 可作为判断病情和评估预后的指标。

关键词: 颅内出血, 白介素-6, 肿瘤坏死因子-α, 新生儿