Abstract: Objective To investigate the association between bisphenol A (BPA) and permature thelarche in infant girls aged 6 months to 2 years old. Methods The blood samples were collected from 40 infants aged 6 months to 2 years old with PT and 32 normal femal infants.The concentration of BPA in serum was determine by using HPLC-MS-MS.The concentration of sex hormones follicule-stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2),prolactin (PRL) in serum were detected by chemiluminescence method at the same time.The difference between the two groups and the correlation between BPA and sex hormones were analysed. Results The relevance ratio and concentration of BPA in PT group were higher than those of the control group (P<0.01).The concentrations of FSH,PRL in the two groups had no statistically significant differences (P>0.05).The concentrations of E2 in PT group was higher than that of the control group (P<0.05).The concentrations of LH of PT group was higher than that of the control group (P<0.01).There were no correlation between the concentrations of BPA and FSH,PRL(P>0.05).There were correlations between the concentrations of BPA and LH,E2(P<0.01). Conclusions 6 months ~2 years old infant girls are under the existence of BPA exposure.BPA exposure is likely one of the causes of PT for 6 months ~2 years old infant girls.BPA exposure maybe affect the secretions of LH and E2.

Key words: bisphenol A, permature thelarche, gonadal hormone

摘要： 目的 研究环境内分泌干扰物双酚A(bisphenol A,BPA)与2岁以下婴幼儿女童乳房发育(permature thelarche,PT)的关系。方法 选择 6月~2岁PT 40例,正常同龄女童32例,利用高效液相色谱串联质谱法(HPLC-MS-MS)进行血清BPA 浓度测定,同时运用化学发光法进行血清性激素浓度:卵泡刺激素(follicule-stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)、雌二醇(estradiol,E2)、泌乳素(prolactin,PRL)测定,比较两组差异及分析BPA与性激素之间相关性。结果 6月~2岁婴幼儿女童PT组血清BPA检出率及浓度均显著高于对照组(P均<0.01)。两组血清FSH,PRL浓度差异无统计学意义(P>0.05),PT组血清E2浓度高于对照组(P<0.05),PT组血清LH浓度高于对照组(P<0.01)。两组血清BPA浓度与FSH浓度、PRL浓度无相关性(P>0.05)。血清BPA浓度与E2和LH浓度有相关性(P<0.01)。结论 6月~2岁婴幼儿女童存在BPA的暴露;BPA暴露可能是6月~2岁婴幼儿女童出现PT的原因之一。6月~2岁婴幼儿女童BPA的暴露可能影响LH及E2的分泌。

关键词: 双酚A, 单纯乳房发育, 性激素