journal1 ›› 2016, Vol. 24 ›› Issue (2): 217-218.DOI: 10.11852/zgetbjzz2016-24-02-32

• Original Articles • Previous Articles     Next Articles

Study on screening cut-off points of the thyroid-stimulating hormone in Anqing

CHEN Shi-qing,CHEN Jun,DENG Hong,WANG Liang-xiu,ZHAO Jing-zhi, LIU Hao,YU Bao-sheng,WU Zhen-zhen,YU Jia,WU Fang   

  1. Maternal and Child Health Care Hospital of Anqing,Anqing,Anhui 246004,China
  • Received:2015-07-02 Online:2016-02-01 Published:2016-02-01

安庆市新生儿先天性甲状腺功能减退症TSH筛查切值探讨

陈实庆,陈军,邓虹,王良秀,赵敬智,刘浩,俞宝圣,吴珍珍,余佳,吴芳   

  1. 安庆市妇幼保健所新生儿疾病筛查中心,安徽 安庆 246004
  • 作者简介:陈实庆(1959-),男,安徽人,主任医师,学士学位,主要研究方向为新生儿生长发育。
  • 基金资助:
    2014年安徽省卫生计生委科研计划项目(14FR011)

Abstract: Objective To know the distribution of TSH and incidence of neonatal congenital hypothyroidism(CH),and study the screening cut-off points of the thyroid-stimulating hormone(TSH)in Anqing. Methods The neonatal screening data about 59 295 newborns in Anqing were analyzed and the TSH cut-off points were calculated by method of percentiles and Receiver Operating Characteristic (ROC)curve,then,the incidence of sufferers was analyzed by different cut-off points. Results The distribution of the neonatal screening data was deflection,P50 was 2.52 mU/L,P99 was 8.94 mU/L.Combined with ROC curve,the cut-off points of our lab was 8.12 mU/L. Conclusions Different cut-off points effect the consequences of the neonatal screening.It is important to establish the suitable cut-off points with ROC curve based on lab.

Key words: congenital hypothyroidism, thyrotropic-stimulating hormone, neonatal screening, ROC curve, cut-off points

摘要: 目的 探讨制定合理的本地新生儿促甲状腺素(TSH)筛查切值。方法 对本市59 295例新生儿TSH筛查结果进行分析,使用百分位数法及ROC曲线法制定TSH筛查切值。结果 新生儿TSH水平呈偏态分布,P25为1.47 mU/L,P50为2.52 mU/L,P75为3.96 mU/L,P95为6.89 mU/L ,P99为8.94 mU/L;ROC曲线法得出本实验室TSH筛查切值为8.12 mU/L。按ROC筛查切值诊断22例先天性甲状腺功能减退症(CH)和28例高TSH血症,若按P99和试剂盒给定的切值标准将漏诊CH患儿1例,漏诊率达4.55%。结论 选用ROC曲线法确定适宜的TSH切值是提高原发性先天性甲状腺功能减退症筛查质量的重要措施。

关键词: 先天性甲状腺功能减退症, 促甲状腺素, 筛查, ROC曲线, 切值

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