Case-control study on gray matter volume in 3~8 years old male children with autism spectrum disorder

doi:10.11852/zgetbjzz2017-25-07-03

Abstract

Abstract: Objective To investigate the changes of the gray matter volume (GMV) in 3~8-year-old male children with autism spectrum disorder (ASD) compared with typically developing male controls (TD) and then assess whether these structural changes were associated with autistic behavioral symptoms. Methods Anatomical T1 images of the whole brain were scanned from 31 ASD male children and 31 normally typically developing male children controls aged 3~8 years.We applied voxel-based morphometry (VBM) techniques to obtain GMV of each brain regions.A voxel-by-voxel two sample t-test combined an Alphasim multiple correction were applied to compare the GMV between ASD group and TD group.The correlations between GMV of the brain regions which showed group difference and the clinical symptom severity were examined. Results Differences were detected in regional GMV between the ASD and TD group.Compaired to control,ASD children showed significantly increased GMV in a large cluster(voxel:z=2 981),including the left superior temporal gyrus (x,y,z:-50.5,-9.5,7.5) and the left postcentral gyrus (x,y,z:-61.5,-7.5,31.5).There was no significant correlation between GMV of the two brain regions and any scores of the ADOS,ADI-R and ABC scores,including the total and subscale scores(P>0.05). Conclusion sGMV of the left superior temporal gyrus and the left postcentral gyrus of 3-8-year-old male children with ASD increase.This study provides an Objective imaging evidence for the pathogenesis of damaged communicational ability and somatosensory anomalies in ASD children.

Key words: autism spectrum disorder, voxel-based morphometry, gray matter volume

摘要： 目的比较3~8岁孤独症谱系障碍(ASD)男童和正常发育男童的大脑灰质体积,为ASD儿童异常行为的神经机制提供脑影像学证据。方法收集31例ASD男童和31例正常发育男童的全脑3DT1结构图像,利用基于体素的形态学测量(VBM)方法计算两组被试大脑各区域的灰质体积,并通过独立样本t检验结合Alphasim多重检验校正发现两组儿童灰质体积存在差异的脑区,将差异区域的灰质体积与临床表型的评估结果进行相关分析。结果与对照组相比,ASD儿童存在一个灰质体积显著增大的团块(体素P<0.001,团块大小=2 981,Alphasim矫正),位于左侧颞上回(x,y,z:-50.5,-9.5,7.5)和左侧中央后回(x,y,z:-61.5,-7.5,31.5)。异常脑区的灰质体积与ADOS、ADI-R和ABC总分及各维度得分并均未发现显著关联(P>0.05)。结论 3~8岁ASD男童左侧颞上回和中央后回灰质体积增大,可作为ASD儿童沟通障碍和感觉异常客观的影像学证据。

关键词: 孤独症谱系障碍, 基于体素的形态学测量, 脑灰质体积

CLC Number:

R179

CHEN Lei, WANG Jia, FU Kuang, WU Qiong, GUO Xiao-nan, WU Li-jie. Case-control study on gray matter volume in 3~8 years old male children with autism spectrum disorder[J]. journal1, 2017, 25(7): 656-659.

陈磊, 王佳, 付旷, 吴琼, 郭肖楠, 武丽杰. 3~8岁孤独症谱系障碍男童脑灰质体积的病例对照研究[J]. 中国儿童保健杂志, 2017, 25(7): 656-659.

0
/ / Recommend

Add to citation manager EndNote|Ris|BibTeX

URL: https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/10.11852/zgetbjzz2017-25-07-03

https://manu41.magtech.com.cn/Jwk_zgetbjzz/EN/Y2017/V25/I7/656

References

[1] American Psychiatric Association.Diagnostic and statistical manual of mental disorders[M].5th Arlington VA,2013:50-58.
[2] Centers for Disease Control and Prevention.Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network,11 sites,United States,2012[J].MMWR Surveill Summ,2016,65(3):1-23.
[3] Centers for Disease Control and Prevention.Prevalence of autism spectrum disorders:autism and developmental monitoring network,14 sites,United States,2002[J].MMWR Surveill Summ,2007,58(1):12-28.
[4] Sun X,Allison C.A review of the prevalence of autism spectrum disorder in Asia[J].Res Autism Spectr Disord,2010,4(2):156-167.
[5] Xiang SUN,Allison C,Matthews FE,et al.Prevalence of autism in mainland China,Hong Kong and Taiwan:a systematic review and meta-analysis[J].Molecular Autism,2013,4(1):1-13.
[6] Hartley SL,Sikora DM.Sex differences in autism spectrum disorder:an examination of developmental functioning,autistic symptoms,and coexisting behavior problems in toddlers[J].J Autism Dev Disord,2009,39(12):1715-1722.
[7] Sipes M,Matson JL,Worley JA,et al.Gender differences in symptoms of autism spectrum disorders in toddlers[J].Res Autism Spectr Disord,2011,5(4):1465-1470.
[8] Carter AS,Black DO,Tewani S,et al.Sex differences in toddlers with autism spectrum disorders[J].J Autism Dev Disord,2007,37(1):86-97.
[9] Frazier TW,Georgiades S,Bishop SL,et al.Behavioral and cognitive characteristics of females and males with autism in the Simons Simplex Collection[J].J Am Acad Child Adolesc Psychiatry,2014,53(3):329-340.
[10] Elsabbagh M,Divan G,Koh YJ,et al.Global prevalence of autism and other pervasive developmental disorders[J].Autism Res,2012,5(3):160-179.
[11] Hazlett HC,Poe M,Gerig G,et al.Magnetic resonance imaging and head circumference study of brain size in autism:birth through age 2 years[J].Archives of General Psychiatry,2010,62(12):1366-1376. [12] Courchesne E,Karns CM,Davis HR,et al.Unusual brain growth patterns in early life in patients with autistic disorder:an MRI study[J].Neurology,2001,57(2):245-254.
[13] Carper RA,Moses P,Tigue ZD,et al.Cerebral lobes in autism:early hyperplasia and abnormal age effects[J].Neuroimage,2002,16(4):1038-1051.
[14] Sparks BF,Friedman SD,Shaw DW,et al.Brain structural abnormalities in young children with autism spectrum disorder[J].Neurology,2002,59(2):184-192.
[15] Schumann CM,Bloss CS,Barnes CC,et al.Longitudinal magnetic resonance imaging study of cortical development through early childhood in autism[J].the Journal of Neuroscience,2010,30(12):4419-4427.
[16] Ecker C,Bookheimer SY,Murphy DG.Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan[J].Lancet Neurology,2015,14(11):1121-1134.
[17] Yang X,Si T,Gong Q,et al.Brain gray matter alterations and associated demographic profiles in adults with autism spectrum disorder:A meta-analysis of voxel-based morphometry studies[J].Aust N Z J Psychiatry,2016,18(3):236-246.
[18] Zhou XIAO,Ting QIU,Xiaoyan KE,et al.Autism spectrum disorder as early neurodevelopmental disorder:evidence from the brain imaging abnormalities in 2-3 years old toddlers[J].J Autism Dev Disord,2014,44(7):1633-1640.
[19] Retico A,Giuliano A,Tancredi R,et al.The effect of gender on the neuroanatomy of children with autism spectrum disorders:a support vector machine case-control study[J].Molecular Autism,2016,7(1):1-20.
[20] Waiter GD,Williams JH,Murray AD,et al.A voxel-based investigation of brain structure in male adolescents with autistic spectrum disorder[J].Neuroimage,2004,22(2):619-625.
[21] Lim L,Chantiluke K,Cubillo AI,et al.Disorder-specific grey matter deficits in attention deficit hyperactivity disorder relative to autism spectrum disorder[J].Psychological Medicine,2015,45(5):965-976.
[22] Leff AP,Schofield TM,Crinion JT,et al.The left superior temporal gyrus is a shared substrate for auditory short-term memory and speech comprehension:evidence from 210 patients with stroke[J].Brain,2009,132(12):3401-3410.
[23] Eyler LT,Pierce K,Courchesne E,et al.A failure of left temporal cortex to specialize for language is an early emerging and fundamental property of autism[J].Brain,2012,135(3):949-960.
[24] Rojas DC,Peterson E,Winterrowd E,et al.Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms[J].BMC Psychiatry,2006,6:56.
[25] Duerden EG,Card D,Roberts SW,et al.Self-injurious behaviours are associated with alterations in the somatosensory system in children with autism spectrum disorder[J].Brain Struct Funct,2014,219(4):1251-1261.
[26] Mahajan R,Dirlikov B,Crocetti D,et al.Motor circuit anatomy in children with autism spectrum disorder with or without attention deficit hyperactivity disorder[J].Autism Research,2016,9(1):67-81.
[27] Cermak SA,Curtin C,Bandini LG.Food selectivity and sensory sensitivity in children with autism spectrum disorders[J].J Am Diet Assoc,2010,110(2):238-246.