Abstract: Objective To investigate the characteristics of auditory brainstem response(ABR) in normal infants aged 1~6 months,and to establish a normal range of the peak latencies(PLs) of wave Ⅰ、Ⅲ、Ⅴ and interpeak latencies(IPLs) of Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ, in order to provide basis for clinic work. Methods Totally 328 infants with normal hearing and 40 adults were tested by ABR from January 2017 to January 2018. The PLs of wave Ⅰ、Ⅲ、Ⅴ and IPLs of Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ from infants of different age groups and ears on different sides were compared. Results The PL of wave I in infants aged 1-6 months was(1.65±0.07),(1.59±0.07),(1.59±0.05),(1.57±0.07),(1.56±0.05) ms and(1.54±0.06) ms,respectively. And the value at the age of 5 months was close to that of adults [(1.53±0.02)ms,P>0.05)]. The PLs of wave Ⅲ、Ⅴ and the IPLs of Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ became shorter with the increase of age,which were(4.04±0.12),(6.11±0.13),(2.50±0.11),(2.07±0.13)ms and(4.57±0.12)ms respectively in infants of 6 months old. But these values were still significantly longer than those of adults[(3.90±0.08),(5.77±0.07),(2.37±0.08) ms,(1.87±0.11)ms and(4.24±0.07)ms,P<0.05)]. No significant differences were found between ages or different side of ears(P>0.05). Conclusion The establishment of normalrange of ABR wave for the infants aged 1 to 6 months will provide reliable basis for early diagnosis and follow-up detection of hearing and development disorders.

Key words: auditory brainstem response, normal range, infants aged 1-6 months

摘要： 目的 探讨1~6月龄正常婴儿脑干听觉诱发电位(ABR)的变化规律,建立婴幼儿ABR波Ⅰ、Ⅲ、Ⅴ潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期的正常值范围,为临床工作提供依据。方法 2017年1月-2018年1月对328名听力正常婴儿和40例成人进行ABR测试。结果 1~6月龄婴儿Ⅰ波潜伏期分别为(1.65±0.07)、(1.59±0.07)、(1.59±0.05)、(1.57±0.07)、(1.56±0.05)ms和(1.54±0.06)ms,该指标至5月龄时已与成人值(1.53±0.02)ms相近(P>0.05);Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期随月龄增长而缩短,至6月龄时各值分别为(4.04±0.12)、(6.11±0.13)、(2.50±0.11)、(2.07±0.13)、(4.57±0.12)ms,但仍未达到成人水平(3.90±0.08)、(5.77±0.07)、(2.37±0.08)、(1.87±0.11)ms和(4.24±0.07)ms,差异有统计学意义(P<0.05)。各波潜伏期及波间期无性别及左右耳差异(P>0.05)。结论 建立1~6月龄婴儿ABR潜伏期及波间期正常值标准,为听力及发育障碍的早期诊断和随访检测提供可靠依据。

关键词: 脑干听觉诱发电位, 正常值范围, 1~6月龄婴儿