Research progress on the correlation between intestinal flora and autism spectrum disorder

doi:10.11852/zgetbjzz2018-1166

Abstract

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterized by social communication disorders, repetitive behaviors and narrow interests.The etiology of ASD is complex, and it focuses on the genetic and environmental factors.As the pathogenesis is unknown, there is no effective treatment.It is found that gastrointestinal diseases and changes of intestinal flora are common in ASD children.Recent studies have shown a two-way interaction between the gut nervous system and the central nervous system, called the microbiota-gut-brain axis.Gut flora regulates brain function through neuroendocrine, immune and intestinal nervous systems and thus affects brain development and behavior.Therefore, the imbalance of intestinal flora may be related to the occurrence of ASD.This article will summarize the effect of intestinal flora on ASD and the progress of related treatment.

Key words: autism spectrum disorder, intestinal flora, microbiota-gut-brain axis

摘要： 孤独症谱系障碍(ASD)是一种主要症状为社会交往障碍、重复刻板行为及狭隘兴趣为特征的神经发育障碍性疾病。病因极为复杂,目前集中在遗传及环境因素两大方面。由于发病机制不明,尚无有效的治疗方法。随着对ASD研究的深入,发现ASD患儿普遍存在胃肠道疾病及肠道菌群的改变。最近的研究显示,肠道神经系统和中枢神经系统之间存在双向互动,称之为微生物-肠-脑轴。肠道菌群通过神经内分泌、神经免疫和肠道神经系统调控大脑功能,进而影响大脑发育和行为。故肠道菌群的失衡可能与ASD的发生有关。本文将总结至今肠道菌群对ASD的作用和相关治疗进展。

关键词: 孤独症谱系障碍, 肠道菌群, 微生物-肠-脑轴

CLC Number:

R749.94

KUNG Wei-yen, WANG Yu. Research progress on the correlation between intestinal flora and autism spectrum disorder[J]. journal1, 2019, 27(4): 407-410.

孔维延, 王瑜. 肠道菌群与孤独症谱系障碍的研究进展[J]. 中国儿童保健杂志, 2019, 27(4): 407-410.

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