Factors in determining the initial colonization of intestinal microbiota in infants

doi:10.11852/zgetbjzz2018-1467

Abstract

Abstract: Normal microbiota of the intestinal tract plays an important role in human health and disease. The alterations in microbial population and profile caused by certain factors may disturb normal physiological functions of human. In this review,the effects of factors on intestinal microbiota were extensively discussed,including gestational age,delivery route,feeding mode,growth environment,antibiotic use,bacterial interference,and application of probiotics.

Key words: normal intestinal microbiota, initial colonization, infants

摘要： 肠道菌群与宿主的健康和疾病有极为密切的关系,多种因素可干扰肠道菌群的构成进而影响宿主的正常生理功能。本文将探讨胎龄、分娩方式、喂养方式、生长环境、抗生素应用、细菌间相互作用和微生态制剂的使用等诸多因素对婴幼儿肠道菌群初始定植的影响。

关键词: 肠道正常菌群, 初始定植, 婴幼儿

CLC Number:

R725

NIE Yao, WANG Zhao-xia. Factors in determining the initial colonization of intestinal microbiota in infants[J]. journal1, 2019, 27(8): 857-860.

聂瑶, 王朝霞. 婴幼儿肠道菌群初始定植的影响因素[J]. 中国儿童保健杂志, 2019, 27(8): 857-860.

References

[1] 韩彤妍,李在玲,叶鸿瑁.新生儿和婴儿肠道菌群的构成及影响因素[J].实用儿科临床杂志,2006,21(2):119-121.
[2] Collado MC,Rautava S,Aakko J,et a1.Human gut colonization may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid[J].Sci Rep,2016,6:23129.doi:10.1038/srep23129.
[3] Stearns JC,Zulyniak MA,de Souza RJ,et al. Ethnic and diet-related differences in the healthy infant microbiome[J].Genome Medicine,2017,9:32.
[4] Jimenez E,Martin R,Martín R,et al.Is meconium from healthy newborns actually sterile? [J]. Res Microbiol,2008,159:187-193.
[5] Chu DM,Ma J,Prince AL,et al. Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery[J]. Nat Med,2017,23:314-326.
[6] Davis M,Zhang H,Brannanl E,et al. Rapid change of fecal microbiome and disappearance of clostridium difficile in a colonized infant after transition from breast milk to cow′s milk[J]. Microbiome,2016,4:53.
[7] Dzidic M,Abrahamsson TR,Artacho A,et al. Aberrant IgA responses to the gut microbiota during infancy precede asthma and allergy development [J]. J Allergy Clin Immunol,2017,139(3):1017-1025.
[8] Slomski A. Human milk protein prevents infections in preterm infants[J]. JAMA,2016,316(20):2078.
[9] Palmer C,Bik EM,DiGiulio DB,et al. Development of the human infant intestinal microbiota[J]. PLoS Biol,2007,5:e177.
[10] Huda MN,Lewis Z,Kalanertra KM,et al. Stool microbiota and vaccine responses of infants[J]. Pediatrics,2014,134(2):e362-e372.
[11] Bokulich NA,Chung J,Battaglia T,et al. Antibiotics,birth mode,and diet shape microbiome maturation during early life[J]. Sci Transl Med,2016,8:343-382.
[12] Dave M,Higgins PD,Middha S,et al. The human gut microbiome:current knowledge,challenges,and futuredirections[J]. Transl Res,2012,160:246-257.
[13] Ferraris L,Butel MJ,Campeotto F,et al.Clostridia in premature neonates′gut:incidence,antibiotic susceptibility,and perinatal determinants influencing colonization[J].PLoS One,2012,7(1) :e30594.
[14] Frese SA,Mills DA.Birth of the infant gut microbiome:moms deliver twice[J].Cell Host Microbe,2015,17(5):543-544.
[15] Dominguez-Bello MG,Costello EK,Contreras M,et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns[J].Proc Natl Acad Sci USA,2010,107(26):11971-11975.
[16] Torun MM,Bahar H,Gur E,et al. Anaerobic fecal flora in healthy breast-fed Turkish babies born by different methods[J].Anaerobe,2002,8(2):63-67.
[17] Bokulich NA,Chung J,Battaglia T,et al. Antibiotica,birth mode,and diet shape microbiome maturation during early life[J].Sci Tranal Med,2016,8(343):343-382.
[18] Mcguire MK,Mcguire MA. Got bacteria? The astounding,yet not-so-surprising,microbiome of human milk[J]. Curr Opin Biotechnol,2017,44:63-68.
[19] Charbonneau MR,Blanton LV,Digiulio DB,et al. A microbial perspective of human developmental biology[J].Nature,2016,535(7610):48-55.
[20] Wopereis H,Sim K,Shaw A,et al. Intestinal microbiota in infants at high risk for allergy:effects of prebiotics and role in eczema development[J].J Allergy Clin Immunol,2018,141(4):1334-1342.
[21] Martin V,Maldonado-Barraganan A,Moles L,et al. Sharing of bacterial strains between breast milk and infant feces[J].J Hum Lact,2012,28(1):36-44.
[22] Bashiardes S,Thaiss CA,Elinav E.It′s in the milk:feeding the microbiome to promote infant growth[J].Cell Metab,2016,23(3):393-394.
[23] Rice TA,Palm NW. Tummy time:the infant microbiota-IgA connection[J]. Cell Host & Microbe,2016,20(1):6-8.
[24] Mastromarino P,Capobianco D,Campagna G,et al.Correlation between lactoferrin and beneficial microbiota in breast milk and infant′s feces[J].Biometals,2014,27(5):1077-1086.
[25] Hassiotou F,Geddes DT. Immune cell-mediated protection of the mammary gland and the infant during breastfeeding[J].Adv Nutr,2015,6(3):267-275.
[26] 吕红艳,王秋丽,杨李红,等.不同喂养方式对极低出生体重儿喂养及肠道菌群的影响[J].中国妇幼卫生杂志,2017,8(4):56-59.
[27] 石塔拉,高蔚娜,郭长江.膳食成分与肠道菌群相互作用[J].营养学报,2016,38(6):530-536.
[28] 杨文翠,张方信,吴文明,等.急进高原大鼠肠道微生态变化的探讨[J].胃肠病学和肝病学杂志,2010,19(6):543-545.
[29] 张方信,杨文翠,邓芝云,等.谷氨酰胺对急进高原大鼠肠道微生态影响的实验研究[J].中国微生态学杂志,2010,22(1):1-4.
[30] Adak A,Ghosh,Mondal KC. Modulation of small intestinal homeostasis along with its microflora during acclimatization at simulated hypobaric hypoxia[J].Indian J Exp Biol,2014,52(11):1098-1105.
[31] Vangay P,Ward T,Gerber JS,et al.Antibiotica,pediatric dysbiosis,and disease[J].Cell Host Microbe,2015,17(5):553-564.
[32] 黄清梅,陆斯良,陈玉君,等.β-内酰胺类抗生素及益生菌干预对晚期早产儿肠道菌群的影响[J].广西医科大学学报,2018,35(5):664-667.
[33] 管利荣,谢坚,何晓芸,等.静脉使用抗生素与小儿肠道菌群变化的相关性分析[J].小儿急救医学,2004,11(6):392-393.
[34] 高岩,苏志暖,郭锡熔.早产儿与足月新生儿血清脂联素水平比较[J] .实用儿科临床杂志,2004,19(12):1043-1044 .
[35] 武斌.肠道营养与儿童健康中国[J].儿童保健杂志,2014,22(7):673-674.
[36] 董红霞,梁浩,闵敏.幽门螺杆菌感染对肠道菌群的影响[J].科技导报,2015,33(7):90-94.
[37] Lau CSM,Chanberlain RS. Probiotic administration can p revent necrotizing enterocolitis in preterm infants:a meta-analysis[J]. J Pediatr Surg,2015,50(8):1405-1412.
[38] 陈琛,江振友,宋克玉,等.中草药对小鼠肠道菌群影响的实验研究[J].中国微生态学杂志,2011,23(1):15-17.
[39] 郭歆岩,赵权,杨桂连.蠕虫对肠道菌群的影响及在宿主免疫中的作用[J].中国人兽共患病学报,2018,34(6):570-573.
[40] Gupta SS,Mohammed MH,Gbosh TS,et al.Metagenome o f the gut of a malnourished child[J].Gut Pathog,2011,3:7.
[41] 陈运旺,陈石娇,林翀.反复肺部感染儿童的肠道状况研究[J].海南医学,2016,27(24):4045-4047.