Abstract: Objective To analyze the association between breastfeeding and childhood autism,in order to provide theoretical basis for the prevention and treatment of autism. Methods Case-control studies on the association between breastfeeding and childhood autism from 2006 to 2017 were analyzed by Meta-analysis with Revman5.3 software.The fixed effect model or random effect model were selected by the heterogeneity test results.The OR value and 95%CI were calculated,publication bias and sensitivity analysis were conducted.Subgroup analysis was conducted according to the breastfeeding duration time (>1 m,>3 m,>6 m,>12 m). Results Totally 11 published articles (13 studies) were selected,including 2 323 cases and 2 839 control cases.The OR and 95%CI of breastfeeding associated with autism were [0.49(0.35~0.68)] (P＜0.05); Subgroup analysis revealed that the values of OR and 95%CI of breastfeeding duration >3 months and >6 months were [0.66(0.49~0.91)] and [0.40(0.32~0.49)](both P＜0.05),respectively. Conclusion Breastfeeding may be a protective factor for childhood autism.So breastfeeding at least for 6 months is suggested to be promoted.

Key words: autism, breastfeeding, case-control study, meta-analysis.

摘要： 目的 分析母乳喂养与儿童孤独症的关系,为孤独症防治提供理论依据。方法 运用Revman 5.3软件,对发表于2006-2017年有关母乳喂养与儿童孤独症关系的病例对照研究进行Meta分析,根据异质性检验结果选择固定效应模型或随机效应模型,计算OR值及95%CI,评估发表偏倚,进行敏感性分析,并对母乳喂养时间按照>1月、>3月、>6月、>12月进行亚组分析。结果 最终选出11篇文献13项研究,累计病例2 323例,对照2 839例。合并效应量结果显示,母乳喂养与孤独症关系的OR值及95%CI为0.49(0.35~0.68) (P＜0.05);亚组分析结果显示,母乳喂养>3月的合并OR值及95%CI为0.66(0.49~0.91)(P＜0.05),母乳喂养>6月的合并OR值及95%CI为0.40 (0.32~0.49)(P＜0.05)。结论 母乳喂养可能是儿童孤独症的保护因素,应提倡母乳喂养至6个月以上。

关键词: 孤独症, 母乳喂养, 病例对照研究, Meta分析