Abstract: Objective To study the relationship between bone mineral density (BMD) and plasma lipid profiles in infants aged 6~12 months,in order to provide guidance for prevention and treatment of osteoporosis in infants. Methods Totally 164 individuals aged 6~12 months were randomly selected from infants undergoing regular physical examination in Maternal and Children's Health Care Hospital of Sanshui District from July 2015 to July 2016. Ultrasound BMD detection and plasma lipid tests were administrated. And participants were divided into 4 groups according to the results of ultrasound BMD, including 30 infants of normal BMD, 50 infants of mild BMD deficiency, 50 infants of moderate BMD deficiency, and 34 infants of severe BMD deficiency. The body length, weight and lipids profiles were compared among all groups. Pearson correlation test was used to analyze the correlation between Z value of BMD and age, body weight, body length, and blood lipid levels. Results There were significant differences on body length, low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) levels in infants among the four groups. Among them, TG level was significantly lower in group with abnormal BMD than in normal group. Pearson correlation analysis showed that Z value of BMD was positively correlated with male gender, age, body length, body weight, TC, LDL-C and TG levels (all P<0.05). Multi-linear regression revealed that TG remained significantly correlated with BMD Z value (β=0.549, P=0.002) after adjusted for age, gender, body weight, body length and TC. Conclusions The level of BMD in infants and young children is closely related to blood lipid levels and body length. So controlling the intake of saturated fatty acids rationally is of great significance to the growth and development as well as osteoporosis prevention in infants.

Key words: bone mineral density, plasma lipid profiles, infant

摘要： 目的 分析6~12月婴幼儿超声骨密度水平与血脂水平的相关性,为婴幼儿骨质疏松的预防和保健提供指导。方法 选取2015年7月—2016年7月在佛山市三水区妇幼保健院门诊健康体检的6~12个月164名婴幼儿进行超声骨密度检测以及血脂4项检测。根据超声骨密度结果分成正常骨密度组(n=30),轻度不足组(n=50),中度不足组(n=50),重度不足组(n=34),对各组的身高、体重及血脂水平进行比较,并分析其与骨密度的相关性。结果 四组婴幼儿的身高、低密度脂蛋白、总胆固醇以及甘油三脂(TG)水平差异有统计学意义,骨密度异常组的TG显著低于正常组(P<0.05);相关分析显示骨密度与男性、年龄、身高、体重、低密度脂蛋白、总胆固醇及TG水平显著正相关。多重线性回归分析显示,在校正了年龄、性别、身高、体重及总胆固醇后,TG和骨密度依然显著正相关(β=0.549,P=0.002)。结论 婴幼儿期的骨密度水平与血脂水平以及身高发育关系密切,合理控制饱和脂肪酸的摄入对促进婴幼儿生长发育、预防骨质疏松具有重要意义。

关键词: 骨密度, 血脂, 婴幼儿