Research progress on perinatal ureaplasma urealyticum infection

doi:10.11852/zgetbjzz2019-0267

Abstract

Abstract: Ureaplasma urealyticum (UU) is a conditionally pathogenic microorganism,which transmits primarily through sexual contact,mother-to-child transmission and iatrogenic transmission.UU infection in adults can lead to nongonococcal urethritis and infertility,and is associated with adverse pregnancy outcomes.Neonatal UU infection can cause chronic pneumonia,bronchopulmonary dysplasia,intraventricular hemorrhage,neonatal meningitis,necrotizing enterocolitis,neonatal retinopathy and so on.Macrolide antibiotics is preferred for UU treatment.The key to preventing UU infection is to strengthen routine UU infection screening in child-bearing women for the purpose of early detection,early diagnosis and early treatment.

Key words: ureaplasma urealyticum, perinatal period, pregnancy outcome

摘要： 解脲脲原体(UU)是一种条件致病微生物,感染传播途径包括性接触传播、母婴传播和医源性传播。成人UU感染可导致非淋菌性尿道炎以及不孕不育,引发各种不良妊娠结局。新生儿UU感染可引起慢性肺炎、支气管肺发育不良、脑室内出血、新生儿脑膜炎、坏死性小肠结肠炎以及早产儿视网膜病变等。UU感染治疗首选大环内酯类抗生素。预防UU感染的关键是加强对育龄期妇女的筛查,早发现早诊断早治疗。

关键词: 解脲脲原体, 围生期, 妊娠结局

CLC Number:

R714.7

LUO Bei, TONG Xiao-mei. Research progress on perinatal ureaplasma urealyticum infection[J]. journal1, 2019, 27(6): 620-623.

罗蓓, 童笑梅. 围生期解脲脲原体感染的研究进展[J]. 中国儿童保健杂志, 2019, 27(6): 620-623.

References

[1] Ng KF,Tan KK,Chok MC,et al.Mycoplasma hominis,Ureaplasma urealyticum and chlamydia trachomatis respiratory colonization in Malaysian preterm infants[J].J Trop Pediatr,2017,63(6): 447-453.
[2] 郑拉洁,苏卫东,黄育丹.34周以下早产儿解脲脲原体感染临床特征分析 [J].临床儿科杂志,2016,34(1): 1-6.
[3] Resch B,Gutmann C,Reiterer F,et al.Neonatal ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics [J].Infection,2016,44(3): 323-327.
[4] Viscardi RM.Ureaplasma species: role in diseases of prematurity [J].Clin Perinatol,2010,37(2): 393-409.
[5] Zeng XY,Xin N,Tong XN,et al.Prevalence and antibiotic susceptibility of ureaplasma urealyticum and mycoplasma hominis in Xi′an,China [J].Eur J Clin Microbiol Infect Dis,2016,35(12): 1941-1947.
[6] Lobão TN,Campos GB,Selis NN,et al.Ureaplasma urealyticum and U.parvum in sexually active women attending public health clinics in Brazil[J].Epidemiol Infect,2017,145(11): 2341-2351.
[7] 陈建飞,钟文华,何缦,等.解脲脲原体感染与早产关系的研究 [J].世界最新医学信息文摘,2015,15(35):36.
[8] Seifoleslami M,Safari A,Khameneie MK.Prevalence of ureaplasma urealyticum and mycoplasma hominis in high vaginal swab samples of infertile females[J].Iran Red Crescent Med J,2015,17(12): e16823.
[9] 辛亚维,张步美,王建梅,等.解脲脲原体感染与女性不孕症的相关性研究[J].中国妇幼保健,2016,31(24): 5444-5446.
[10] Qian L,Bian GR,Li HB,et al.Effects of ureaplasma urealyticum infection on sperm quality and concentrations of nitric oxide and cytokine in the semen of infertile males [J].Am J Reprod Immunol,2016,75(6): 605-608.
[11] Huang C,Long X,Jing S,et al.Ureaplasma urealyticum and Mycoplasma hominis infections and semen quality in 19,098 infertile men in China [J].World J Urol,2016,34(7): 1039-1044.
[12] 童郁,邵展,戴显宁,等.RNA恒温扩增技术诊断新生儿解脲脲原体感染的价值 [J].中国新生儿科杂志,2017,32(5): 371-373.
[13] Gancia P,Delogu A,Pomero G.Ureaplasma and bronchopulmonary dysplasia [J].Early Hum Dev,2014,90(Suppl 1): 39-41.
[14] 董孝云,张璋,熊虹: 阿奇霉素治疗早产儿解脲脲原体感染的疗效观察 [J].中国实用医药,2016,11(1):123-124.
[15] Suri NA,Sebastian S,Yadav D,et al.A case of oropharyngeal Ureaplasma urealyticum infection in a human immunodeficiency virus positive bisexual male co-infected with human papilloma virus and treponema pallidum [J].JMM Case Rep,2018,5(3):e005132.
[16] Lanzafame M,Delama A,Lattuada E,et al.Prevalence and clinical significance of ureaplasma urealyticum and Mycoplasma hominis in the lower genital tract of HIV-1-infected women [J].Infez Med,2006,14(4):213-215.
[17] Yeo TH,Seok WI,Kim HY.Detection and culture of ureaplasma urealyticum in ovarian cancer [J].Korean J Obstet Gynecol,2001,44(5):877-884.
[18] Ollikainen J.Perinatal ureaplasma urealyticum infection increases the need for hospital treatment during the first year of life in preterm infants [J].Pediatr Pulmonol,2000,30(5): 402-405.
[19] Viscardi RM.Ureaplasma species: role in neonatal morbidities and outcomes [J].Arch Dis Child Fetal Neonatal Ed,2014,99(1): F87- F92.
[20] Viscardi RM,Kallapur SG.Role of ureaplasma respiratory tract colonization in bronchopulmonary dysplasia pathogenesis: current concepts and update [J].Clin Perinatol,2015,42(4): 719-738.
[21] Lowe J,Watkins WJ,Edwards MO,et al.Association between pulmonary ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis [J].Pediatr Infect Dis J,2014,33(7): 697-702.
[22] 范礼英,周利平.早产儿呼吸道分泌物解脲脲原体阳性与新生儿肺损伤的关系 [J].医学临床研究,2016,33(12): 2329-2331.
[23] Okogbule-Wonodi AC,Gross GW,Sun CC,et al.Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants [J].Pediatr Res,2011,69(5 Pt 1):442-447.
[24] Normann E,Lacaze-Masmonteil T,Eaton F,et al.A novel mouse model of ureaplasma-induced perinatal inflammation: effects on lung and brain injury [J].Pediatr Res,2009,65(4): 430-436.
[25] Viscardi RM,Hashmi N,Gross GW,et al.Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage[J].J Perinatol,2008,28(11): 759-765.
[26] Berger A,Witt A,Haiden N,et al.Intrauterine infection with ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants [J].J Perinat Med,2009,37(1): 72-78.
[27] Ozdemir R,Sari FN,Tunay ZO,et al.The association between respiratory tract ureaplasma urealyticum colonization and severe retinopathy of prematurity in preterm infants ≤1250 g [J].Eye (Lond),2012,26(7): 992-996.
[28] Zhou LJ,Lian DS,Kai XU,et al.Effect evaluation of present liquid culture detection method for ureaplasma urealyticum[J].Chinese Journal of Zoonoses,2015,31(1): 16-20.
[29] Zhang Y,Hua C,Li SL.The relationship between the biovars and the antimicrobial resistance of ureaplasma urealyticum in female patients with urogenital infections [J].J Clin Lab Anal,2017,32(1): e22211.