Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (12): 1309-1312.DOI: 10.11852/zgetbjzz2020-2064

• Review • Previous Articles     Next Articles

New progress in the pathogenesis of neonatal necrotizing enterocolitis

LIU Na, LI Zhong-liang, ZHANG Chun-lei, LI Xue-feng, ZHANG Cheng-yuan, ZHANG Xue-bo   

  1. Weifang Maternal and Child Health Hospatal, Weifang, Shandong 261000, China
  • Received:2020-12-02 Revised:2021-02-05 Published:2021-12-09
  • Contact: ZHANG Chun-lei, E-mail:


刘娜, 李忠良, 张春磊, 李雪峰, 张成元, 张学博   

  1. 潍坊市妇幼保健院新生儿科,山东 潍坊 261000
  • 通讯作者: 张春磊,
  • 作者简介:刘娜(1989-),女,山东人,主治医师,硕士研究生,主要研究方向为新生儿疾病。

Abstract: Necrotizing enterocolitis (NEC) is one of the diseases with high morbidity and mortality in neonates. Although the clinical diagnosis, treatment and nursing of newborns have improved, the unclear pathogenesis is still the main reason that limits the prognosis of NEC. In recent years, new progress has been made in the research of the pathogenesis of NEC, including the modulation of vascular endothelial growth factor, the signal transduction of Toll-like receptors, the discovery of potential biomarkers of NEC through metabolomics, probing for genetic predispositions to NEC susceptibility, determining mechanistic relations between anemia, intestinal flora imbalance and NEC. In-depth understanding of the pathogenesis of NEC will help to further improve the diagnosis and treatment of this disease. In this article, these new insights will be reviewed.

Key words: necrotizing enterocolitis, pathogenesis, newborn

摘要: 新生儿坏死性小肠结肠炎(NEC)是新生儿发病率和死亡率较高的疾病之一。 尽管新生儿的临床诊疗和护理等措施有所进步,但其未完全明确的发病机制仍是限制该疾病预后的主要原因。近几年,对该疾病发病机制的研究有了新的进展,包括血管内皮生长因子的调节,Toll 样受体的信号转导,通过代谢组学发现NEC潜在的生物标志物,探索NEC的遗传易感性,明确贫血和肠道菌群失调与NEC之间的关系。通过对NEC发病机理的深入了解有助于进一步提高对该疾病的诊疗。本文将对这些新的观点进行综述。

关键词: 坏死性小肠结肠炎, 发病机制, 新生儿

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